ReviewFrontiers in physiology2017
Defining the Balance between Regeneration and Pathological Ossification in Skeletal Muscle Following Traumatic Injury.
Review in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Regenerative response of rat skeletal muscle to the implantation of a collagen-based bone graft substitute: anEuropean journal of translational myology · 2025Article
- From inflammation to bone formation: the intricate role of neutrophils in skeletal muscle injury and traumatic heterotopic ossification.Experimental & molecular medicine · 2024Review
- The Kinesin GeneInternational journal of molecular sciences · 2022Article
- Disruption of the mouse Bmal1 locus promotes heterotopic ossification with aging via TGF-beta/BMP signaling.Journal of bone and mineral metabolism · 2022Article
- Case Report: Unable to Jump Like a Kangaroo Due to Myositis Ossificans Circumscripta.Frontiers in veterinary science · 2022Article
- Article
- Description and etiology of paleopathological lesions in the type specimen of Parasaurolophus walkeri (Dinosauria: Hadrosauridae), with proposed reconstructions of the nuchal ligament.Journal of anatomy · 2020Article
- Genetic correlations between cartilage regeneration and degeneration reveal an inverse relationship.Osteoarthritis and cartilage · 2020Article
- Gene activated adipose tissue fragments as advanced autologous biomaterials for bone regeneration: osteogenic differentiation within the tissue and implications for clinical translation.Scientific reports · 2019Article
- BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification.Stem cell research & therapy · 2019Article
- A Muscle Stem Cell Support Group: Coordinated Cellular Responses in Muscle Regeneration.Developmental cell · 2018Review
- Treatments and Preventative Measures for Trauma-Induced Heterotopic Ossification: A Review.Clinical and translational science · 2018Review
- Article
- miR-24 and miR-122 Negatively Regulate the Transforming Growth Factor-β/Smad Signaling Pathway in Skeletal Muscle Fibrosis.Molecular therapy. Nucleic acids · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Heterotopic ossification (HO) is characterized by the formation of bone at atypical sites. This type of ectopic bone formation is most prominent in skeletal muscle, most frequently resulting as a consequence of physical trauma and associated with aberrant tissue regeneration. The condition is debilitating, reducing a patient's range of motion and potentially causing severe pathologies resulting from nerve and vascular compression. Despite efforts to understand the pathological processes governing HO, there remains a lack of consensus regarding the micro-environmental conditions conducive to its formation, and attempting to define the balance between muscle regeneration and pathological ossification remains complex. The development of HO is thought to be related to a complex interplay between factors released both locally and systemically in response to trauma. It develops as skeletal muscle undergoes significant repair and regeneration, and is likely to result from the misdirected differentiation of endogenous or systemically derived progenitors in response to biochemical and/or environmental cues. The process can be sequentially delineated by the presence of inflammation, tissue breakdown, adipogenesis, hypoxia, neo-vasculogenesis, chondrogenesis and ossification. However, exactly how each of these stages contributes to the formation of HO is at present not well understood. Our previous review examined the cellular contribution to HO. Therefore, the principal aim of this review will be to comprehensively outline changes in the local tissue micro-environment following trauma, and identify how these changes can alter the balance between skeletal muscle regeneration and ectopic ossification. An understanding of the mechanisms governing this condition is required for the development and advancement of HO prophylaxis and treatment, and may even hold the key to unlocking novel methods for engineering hard tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.