ArticleFrontiers in neuroscience2017
Electrical Stimulation of Afferent Pathways for the Suppression of Pathological Tremor.
Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Peripherical Electrical Stimulation for Parkinsonian Tremor: A Systematic Review.Frontiers in aging neuroscience · 2022Pooled it
- Need for mechanically and ergonomically enhanced tremor-suppression orthoses for the upper limb: a systematic review.Journal of neuroengineering and rehabilitation · 2019Pooled it
- An Acute Randomized Controlled Trial of Noninvasive Peripheral Nerve Stimulation in Essential Tremor.Neuromodulation : journal of the International Neuromodulation Society · 2019Trial
- Wearable Ultrasound Sensing with Dual Arrays and Machine Learning for Real-Time Tremor Characterization and Antagonist Muscle Monitoring.IEEE transactions on instrumentation and measurement · 2026Article
- Ultrasound-Informed State Estimation of Wrist Tremor Dynamics via Koopman Operator for Personalized Sensory Peripheral Nerve Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Ultrasound Imaging Triggered Tremor Suppression With Personalized Afferent Stimulation Frequency.IEEE transactions on bio-medical engineering · 2025Article
- Improving Wrist Tremor Suppression via Targeted Application of Afferent and Interferential Stimulation Techniques.IEEE ... International Conference on Rehabilitation Robotics : [proceedings] · 2025Article
- Targeting the fundamentals for tremors: the frequency and amplitude coding in essential tremor.Journal of biomedical science · 2025Review
- Potential of Individual Upper-Limb Muscles to Contribute to Postural Tremor: Simulations From Neural Drive to Joint Rotation.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Learning to suppress tremors: a deep reinforcement learning-enabled soft exoskeleton for Parkinson's patients.Frontiers in robotics and AI · 2025Article
- Electrical stimulation in upper limb assistance: opportunities and challenges.Frontiers in neuroscience · 2025Review
- Spatial Augmented Reality for Expanding the Reach of Individuals with Tremor beyond Their Physical Limits.Sensors (Basel, Switzerland) · 2024Article
- Towards Ultrasound Imaging-based Closed-loop Peripheral Nerve Stimulation for Tremor Suppression.Current opinion in biomedical engineering · 2023Article
- Classification of Kinematic and Electromyographic Signals Associated with Pathological Tremor Using Machine and Deep Learning.Entropy (Basel, Switzerland) · 2023Article
- Brief Submotor-Threshold Electrical Stimulation Applied Synchronously Over Wrist Flexor and Extensor Muscles does Not Suppress Essential Tremor, Independent of Stimulation Frequency.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Article
- A review of combined neuromodulation and physical therapy interventions for enhanced neurorehabilitation.Frontiers in human neuroscience · 2023Review
- Non-invasive electrical stimulation of peripheral nerves for the management of tremor.Journal of the neurological sciences · 2022Review
- Analyzing the Effects of Parameters for Tremor Modulation via Phase-Locked Electrical Stimulation on a Peripheral Nerve.Journal of personalized medicine · 2022Article
- Rationale and Evidence for Peripheral Nerve Stimulation for Treating Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022Review
- Identifying and modulating distinct tremor states through peripheral nerve stimulation in Parkinsonian rest tremor.Journal of neuroengineering and rehabilitation · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathological tremors are involuntary oscillatory movements which cannot be fully attenuated using conventional treatments. For this reason, several studies have investigated the use of neuromuscular electrical stimulation for tremor suppression. In a recent study, however, we found that electrical stimulation below the motor threshold also suppressed tremor, indicating involvement of afferent pathways. In this study, we further explored this possibility by systematically investigating how tremor suppression by afferent stimulation depends on the stimulation settings. In this way, we aimed at identifying the optimal stimulation strategy, as well as to elucidate the underlying physiological mechanisms of tremor suppression. Stimulation strategies varying the stimulation intensity and pulse timing were tested in nine tremor patients using either intramuscular or surface stimulation. Significant tremor suppression was observed in six patients (tremor suppression > 75% was observed in three patients) and the average optimal suppression level observed across all subjects was 52%. The efficiency for each stimulation setting, however, varied substantially across patients and it was not possible to identify a single set of stimulation parameters that yielded positive results in all patients. For example, tremor suppression was achieved both with stimulation delivered in an out-of-phase pattern with respect to the tremor, and with random timing of the stimulation. Overall, these results indicate that low-current stimulation of afferent fibers is a promising approach for tremor suppression, but that further research is required to identify how the effect can be maximized in the individual patient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.