ArticleScientific reports2017
Synergistic Antimicrobial Effects of Silver/Transition-metal Combinatorial Treatments.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 103 citations in OpenAlex.
- Antibiotic-Free Strategies for Managing Antimicrobial-Resistant Infections.Pharmaceutics · 2026Review
- Drinking Water Disinfection Using Nutritional Level Zinc Assisted with Electric Field Treatment.Environmental science & technology · 2026Article
- Assessing non-porous antimicrobial surfaces against bacteria, phages and fungi: a comparative study under varied normative conditions using glass as a benchmark for microbial persistence.BMC microbiology · 2026Article
- Article
- Combined antimicrobial and anti-inflammatory properties of electrospun PCL nanohybrids infused with metal-turmeric oleoresin and metalcurcuminoids.RSC advances · 2025Article
- Identification and mitigation of blood's interference with the antimicrobial activity of AgNbO3 particles.PloS one · 2025Article
- Antimicrobial coatings effectively inactivate multidrug-resistantFrontiers in microbiology · 2025Article
- Benefits of Core-Shell Particles over Single-Metal Coatings: Mechanical and Chemical Exposure and Antimicrobial Efficacy.Polymers · 2024Article
- Novel antimony-based antimicrobial drug targets membranes of Gram-positive and Gram-negative bacterial pathogens.Microbiology spectrum · 2024Article
- Ag-NP-Decorated Carbon Nanostructures: Synthesis, Characterization, and Antimicrobial Properties.ACS omega · 2024Article
- A new method for testing non-porous surfaces for their antimicrobial efficacy using an aerosol-generating spray chamber.Frontiers in microbiology · 2024Article
- Study on the Antibacterial Activity and Bone Inductivity of Nanosilver/PLGA-Coated TI-CU Implants.International journal of nanomedicine · 2024Article
- Synthesis, Characterization, and Bioactivity of Mesoporous Bioactive Glass Codoped with Zinc and Silver.International journal of molecular sciences · 2023Article
- Synergistic antibacterial effect of copper and silver nanoparticles and their mechanism of action.Scientific reports · 2023Article
- Synergistic antibacterial mechanism of silver-copper bimetallic nanoparticles.Frontiers in bioengineering and biotechnology · 2023Review
- The Study of Nanosized Silicate-Substituted Hydroxyapatites Co-Doped with SrCurrent issues in molecular biology · 2022Article
- The mechanism of metal-based antibacterial materials and the progress of food packaging applications: A review.Ceramics international · 2022Review
- Article
- Combination Strategies of Different Antimicrobials: An Efficient and Alternative Tool for Pathogen Inactivation.Biomedicines · 2022Review
- Novel Fusidic Acid Cream Containing Metal Ions and Natural Products against Multidrug-Resistant Bacteria.Pharmaceutics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to the emergence of multi-drug resistant strains, development of novel antibiotics has become a critical issue. One promising approach is the use of transition metals, since they exhibit rapid and significant toxicity, at low concentrations, in prokaryotic cells. Nevertheless, one main drawback of transition metals is their toxicity in eukaryotic cells. Here, we show that the barriers to use them as therapeutic agents could be mitigated by combining them with silver. We demonstrate that synergism of combinatorial treatments (Silver/transition metals, including Zn, Co, Cd, Ni, and Cu) increases up to 8-fold their antimicrobial effect, when compared to their individual effects, against E. coli and B. subtilis. We find that most combinatorial treatments exhibit synergistic antimicrobial effects at low/non-toxic concentrations to human keratinocyte cells, blast and melanoma rat cell lines. Moreover, we show that silver/(Cu, Ni, and Zn) increase prokaryotic cell permeability at sub-inhibitory concentrations, demonstrating this to be a possible mechanism of the synergistic behavior. Together, these results suggest that these combinatorial treatments will play an important role in the future development of antimicrobial agents and treatments against infections. In specific, the cytotoxicity experiments show that the combinations have great potential in the treatment of topical infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.