Evidence map›Paper›PMID 28420827›Full record

ArticleCirculation journal : official journal of the Japanese Circulation Society2017

Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms.

Deborah A Howatt, Maya Dajee, Xiaojie Xie, Jessica Moorleghen, Debra L Rateri, Anju Balakrishnan, Valdeci Da Cunha, Douglas G Johns, David E Gutstein, Alan Daugherty and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Circulation journal : official journal of the Japanese Circulation Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Deborah A HowattSaha Cardiovascular Research Center, University of Kentucky.
Maya DajeeCardio-Metabolic Diseases, Merck Research Laboratories, Cardiovascular Research Center, Merck & Co., Inc.
Xiaojie XieSaha Cardiovascular Research Center, University of Kentucky.
Jessica MoorleghenSaha Cardiovascular Research Center, University of Kentucky.
Debra L RateriSaha Cardiovascular Research Center, University of Kentucky.
Anju BalakrishnanSaha Cardiovascular Research Center, University of Kentucky.
Valdeci Da CunhaCardio-Metabolic Diseases, Merck Research Laboratories, Cardiovascular Research Center, Merck & Co., Inc.
Douglas G JohnsCardio-Metabolic Diseases, Merck Research Laboratories, Cardiovascular Research Center, Merck & Co., Inc.
David E GutsteinCardio-Metabolic Diseases, Merck Research Laboratories, Cardiovascular Research Center, Merck & Co., Inc.
Alan DaughertySaha Cardiovascular Research Center, University of Kentucky.
Hong LuSaha Cardiovascular Research Center, University of Kentucky.
University of Kentucky · US

Funding

Adventitial-medial interactions in thoracic aortic diseasesR01HL133723 · NHLBI · UNIVERSITY OF KENTUCKY · PI DAUGHERTY, ALAN · 2016 to 2019
$2.9M
Mechanisms of thoracic aortic aneurysmsR01HL107319 · NHLBI · UNIVERSITY OF KENTUCKY · PI DAUGHERTY, ALAN · 2012 to 2015
$2.1M
NHLBI NIH HHS R01 HL107319NHLBI NIH HHS R01 HL133723
6 · The paper itself

Abstract

backgroundThis study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA). METHODS AND 

resultsMale C57BL/6 or apolipoprotein E

conclusionsMMP-9 deficiency augmented AngII-induced AAA.

Indexed as

Angiotensin IIAnimalsAortic Aneurysm, AbdominalApolipoproteins EMatrix Metalloproteinase 9MiceMice, KnockoutRelaxinAngiotensin IIApolipoproteins EMatrix Metalloproteinase 9Mmp9 protein, mouseRelaxinAbdominal aortic aneurysmMatrix metalloproteinaseRelaxin

Identifiers

PMID28420827
PMCPMC5964022
OpenAlexW2606739237

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.