ArticleThe Journal of veterinary medical science2017
Listeria monocytogenes serotype 4b strains replicate in monocytes/macrophages more than the other serotypes.
Article in The Journal of veterinary medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Current methodologies available to evaluate the virulence potential amongFrontiers in microbiology · 2024Review
- Design and 3D printing of an electrochemical sensor forHeliyon · 2023Article
- TMT-Based Quantitative Proteomic Analysis of Intestinal Organoids Infected byInternational journal of molecular sciences · 2022Article
- Phage Display-Derived Monoclonal Antibodies Against Internalins A and B Allow Specific Detection ofFrontiers in public health · 2022Article
- Whole-Genome Sequencing-Based Characterization of aMicroorganisms · 2021Article
- Characterization of a Novel Group ofViruses · 2021Article
- Proteomic Exploration ofInternational journal of peptide research and therapeutics · 2021Article
- Article
- Chlamydia Spreading from the Genital Tract to the Gastrointestinal Tract - A Two-Hit Hypothesis.Trends in microbiology · 2018Review
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
We analyzed the pathogenicity of various serotypes of Listeria monocytogenes using a Balb/c mouse intravenous injection model. The survival rates of mice inoculated with strains NS1/2b (serotype 1/2b), NS3b (serotype 3b) and NS 4b (serotype 4b) were 60, 63.6 and 63.6%, respectively. Although the survival rates were similar, the bacterial growth in the liver of NS3b-infected mice was 144.5-fold higher than that in the liver of NS4b-infected mice. Histopathological analyses suggest that the NS4b strain replicated more in monocytes/macrophages, whereas the NS3b strain replicated more in hepatocytes. These results raise a possibility that the serotype 4b strains replicated more in monocytes/macrophages compared to the other serotype strains. To assess this, we isolated CD11b-positive cells from mouse livers infected with EGDe (serotype 1/2a), NS1/2b, NS3b, NS4b and the serotype 4b strains 51414 and F17 and counted the number of live bacteria in these cells. CD11b-positive cells from the NS4b-, 51414- and F17-infected mice possessed 24.4- to 42.7-fold higher numbers of live bacteria than those from mice infected with EGDe and NS3b strains. These results suggest that serotype 4b strains replicated more in monocytes/macrophages than the other serotypes, and this may be involved in the pathogenicity of serotype 4b strains, particularly in the dissemination of L. monocytogenes through the host body.
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