Evidence map›Paper›PMID 28420718›Full record

ArticleEndocrine connections2017

Sex, BMI and age differences in metabolic syndrome: the Dutch Lifelines Cohort Study.

Sandra N Slagter, Robert P van Waateringe, André P van Beek, Melanie M van der Klauw, Bruce H R Wolffenbuttel, Jana V van Vliet-Ostaptchouk

Open access · goldAbstract read
In one paragraph

Article in Endocrine connections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  7. Obesity and metabolic syndrome in adults with a 22q11.2 microdeletion.International journal of obesity (2005) · 2025
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  11. Does Body Mass Index Affect Postural Control in Adults?International journal of exercise science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sandra N SlagterDepartment of EndocrinologyUniversity of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Robert P van WaateringeDepartment of EndocrinologyUniversity of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
André P van BeekDepartment of EndocrinologyUniversity of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Melanie M van der KlauwDepartment of EndocrinologyUniversity of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Bruce H R WolffenbuttelDepartment of EndocrinologyUniversity of Groningen, University Medical Center Groningen, Groningen, The Netherlands bwo@umcg.nl.
Jana V van Vliet-OstaptchoukDepartment of EndocrinologyUniversity of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTo evaluate the prevalence of metabolic syndrome (MetS) and its individual components within sex-, body mass index (BMI)- and age combined clusters. In addition, we used the age-adjusted blood pressure thresholds to demonstrate the effect on the prevalence of MetS and elevated blood pressure. SUBJECTS AND

methodsCross-sectional data from 74,531 Western European participants, aged 18-79 years, were used from the Dutch Lifelines Cohort Study. MetS was defined according to the revised NCEP-ATPIII. Age-adjusted blood pressure thresholds were defined as recommended by the eight reports of the Joint National Committee (≥140/90 mmHg for those aged <60 years, and ≥150/90 mmHg for those aged ≥60 years).

results19.2% men and 12.1% women had MetS. MetS prevalence increased with BMI and age. Independent of BMI, abdominal obesity dominated MetS prevalence especially in women, while elevated blood pressure was already highly prevalent among young men. Applying age-adjusted blood pressure thresholds resulted in a 0.2-11.9% prevalence drop in MetS and 6.0-36.3% prevalence drop in elevated blood pressure, within the combined sex, BMI and age clusters.

conclusionsWe observed a gender disparity with age and BMI for the prevalence of MetS and, especially, abdominal obesity and elevated blood pressure. The strict threshold level for elevated blood pressure in the revised NCEP-ATPIII, results in an overestimation of MetS prevalence.

Indexed as

age adjustedblood pressureBMImetabolic syndromepopulation basedsex

Identifiers

PMID28420718
PMCPMC5457493
OpenAlexW2606338153

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.