Evidence map›Paper›PMID 28420660›Full record

ArticleBMJ open2017

Education achievement and type 2 diabetes-what mediates the relationship in older adults? Data from the ESTHER study: a population-based cohort study.

Christopher J Steele, Ben Schöttker, Adele H Marshall, Anne Kouvonen, Mark G O'Doherty, Ute Mons, Kai-Uwe Saum, Paolo Boffetta, Antonia Trichopoulou, Hermann Brenner and 1 more

Abstract read
In one paragraph

Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  8. Increases in Psychological Stress Are Associated With Higher Fasting Glucose in US Chinese Immigrants.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2024
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  17. Levels and Correlates of Numeracy Skills in Lebanese Adults with Diabetes: A Cross-Sectional Study.International journal of environmental research and public health · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christopher J SteeleUKCRC Centre of Excellence for Public Health, Queen's University Belfast, Belfast, UK csteele09@qub.ac.uk.
Ben SchöttkerGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Adele H MarshallUKCRC Centre of Excellence for Public Health, Queen's University Belfast, Belfast, UK.
Anne KouvonenSocial Research, University of Helsinki, Helsinki, Finland.
Mark G O'DohertyUKCRC Centre of Excellence for Public Health, Queen's University Belfast, Belfast, UK.
Ute MonsGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Kai-Uwe SaumGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Paolo BoffettaThe Tisch Cancer Institute and Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece.
Hermann BrennerGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Frank KeeUKCRC Centre of Excellence for Public Health, Queen's University Belfast, Belfast, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe study aims to identify the mediating factors of the relationship between education achievement and incident type 2 diabetes mellitus (T2DM) in older adults.

designPopulation-based cohort study.

settingParticipants were recruited from the German federal state of Saarland.

participantsParticipants were excluded if they had prevalent T2DM or missing data on prevalent T2DM, missing or zero follow-up time for incident T2DM or were under 50 years of age. The total sample consisted of 7462 individuals aged 50-75 years (42.8% men, mean age 61.7 years) at baseline (2000-02). The median follow-up time was 8.0 years.

methodsCox proportional hazards regression was initially used to determine the direct association between education achievement and incident T2DM. Using the Baron and Kenny approach, we then investigated the associations between education achievement and incident T2DM with the potential mediators. The contribution of each of the putative mediating variables was then calculated.

resultsA clear socioeconomic gradient was observed with regard to T2DM incidence with the lowest educated individuals at a greater risk of developing the disease during the follow-up period: HR (95% CI) high education: 0.52 (0.34 to 0.80); medium education: 0.80 (0.66 to 0.96). Seven of the variables considered explained a proportion of the education-T2DM relationship (body mass index, alcohol consumption, hypertension, fasting triglycerides, high-density lipoprotein (HDL) cholesterol, physical activity and smoking status), where the contribution of the variables ranged from 1.0% to 17.7%. Overall, the mediators explained 31.7% of the relationship.

conclusionBy identifying the possible mediating factors of the relationship between education achievement and incident T2DM in older adults, the results of this study can be used to assist with the development of public health strategies that aim to reduce socioeconomic inequalities in T2DM.

Indexed as

Educational StatusExerciseAgedAlcohol DrinkingBody Mass IndexCholesterol, HDLCohort StudiesDiabetes Mellitus, Type 2DyslipidemiasFemaleGermanyHumansHypertensionIncidenceMaleMiddle AgedCholesterol, HDLTriglyceridesmediationolder adultssocioeconomic positionType 2 diabetes mellitus

Identifiers

PMID28420660
PMCPMC5719655

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.