Evidence map›Paper›PMID 28420458›Full record

ArticleDevelopment and psychopathology2018

Potentially important periods of change in the development of social and role functioning in youth at clinical high risk for psychosis.

Eva Velthorst, Jamie Zinberg, Jean Addington, Kristin S Cadenhead, Tyrone D Cannon, Ricardo E Carrión, Andrea Auther, Barbara A Cornblatt, Thomas H McGlashan, Daniel H Mathalon and 7 more

Abstract read
In one paragraph

Article in Development and psychopathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Trial
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  18. Associations of psychotic-like experiences, related symptoms, and working memory with functioning.European psychiatry : the journal of the Association of European Psychiatrists · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Eva VelthorstIcahn School of Medicine at Mount Sinai.
Jamie ZinbergUniversity of California, Los Angeles.
Jean AddingtonUniversity of Calgary.
Kristin S CadenheadUniversity of California, San Diego.
Tyrone D CannonYale University.
Ricardo E CarriónHofstra Northwell School of Medicine.
Andrea AutherHofstra Northwell School of Medicine.
Barbara A CornblattHofstra Northwell School of Medicine.
Thomas H McGlashanYale University.
Daniel H MathalonUniversity of California, San Francisco.
Diana O PerkinsUniversity of North Carolina, Chapel Hill.
Larry J SeidmanHarvard Medical School at Beth Israel Deaconess Medical Center.
Ming T TsuangUniversity of California, San Diego.
Elaine F WalkerEmory University.
Scott W WoodsYale University.
Abraham ReichenbergIcahn School of Medicine at Mount Sinai.
Carrie E BeardenUniversity of California, Los Angeles.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
1/9 Predictors and Mechanisms of Conversion to PsychosisU01MH081902 · NIMH · YALE UNIVERSITY · PI CANNON, TYRONE D · 2008 to 2018
$12.4M
5/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082004 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PERKINS, DIANA O. · 2008 to 2018
$7.5M
Administrative Supplement Harmonization of At Risk Multisite Observational Networks for Youth(HARMONY)U01MH081928 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI STONE, WILLIAM SETH · 2008 to 2018
$7.1M
4/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081857 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CORNBLATT, BARBARA A. · 2008 to 2018
$6.2M
8/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082022 · NIMH · YALE UNIVERSITY · PI WOODS, SCOTT W · 2008 to 2018
$6.0M
2/9 - Predictors and Mechanisms of Conversion to PsychosisU01MH081988 · NIMH · EMORY UNIVERSITY · PI WALKER, ELAINE FRAN · 2008 to 2018
$5.4M
6/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081944 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2008 to 2018
$4.9M
"7/9" Predictors and Mechanisms of Conversion to PsychosisU01MH081984 · NIMH · UNIVERSITY OF CALGARY · PI ADDINGTON, JEAN M · 2008 to 2018
$4.2M
VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIAR01MH060720 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2000 to 2010
$4.0M
9/9-Predictors and Mechanisms of Conversion to PsychosisU01MH076989 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MATHALON, DANIEL H · 2014 to 2018
$3.9M
CHARACTERIZATION OF PRODROMAL SCHIZOPHRENIAR01MH061523 · NIMH · LONG ISLAND JEWISH MEDICAL CENTER · PI CORNBLATT, BARBARA A. · 2000 to 2009
$3.6M
NCATS NIH HHS UL1 TR001863NIMH NIH HHS K05 MH001654NIMH NIH HHS K23 MH001905NIMH NIH HHS R01 MH060720NIMH NIH HHS R01 MH061523NIMH NIH HHS R01 MH062066NIMH NIH HHS R01 MH065079NIMH NIH HHS R01 MH107250NIMH NIH HHS U01 MH066069NIMH NIH HHS U01 MH066134NIMH NIH HHS U01 MH066160NIMH NIH HHS U01 MH076989NIMH NIH HHS U01 MH081857NIMH NIH HHS U01 MH081902NIMH NIH HHS U01 MH081928NIMH NIH HHS U01 MH081944NIMH NIH HHS U01 MH081984NIMH NIH HHS U01 MH081988NIMH NIH HHS U01 MH082004NIMH NIH HHS U01 MH082022
6 · The paper itself

Abstract

The developmental course of daily functioning prior to first psychosis-onset remains poorly understood. This study explored age-related periods of change in social and role functioning. The longitudinal study included youth (aged 12-23, mean follow-up years = 1.19) at clinical high risk (CHR) for psychosis (converters [CHR-C], n = 83; nonconverters [CHR-NC], n = 275) and a healthy control group (n = 164). Mixed-model analyses were performed to determine age-related differences in social and role functioning. We limited our analyses to functioning before psychosis conversion; thus, data of CHR-C participants gathered after psychosis onset were excluded. In controls, social and role functioning improved over time. From at least age 12, functioning in CHR was poorer than in controls, and this lag persisted over time. Between ages 15 and 18, social functioning in CHR-C stagnated and diverged from that of CHR-NC, who continued to improve (p = .001). Subsequently, CHR-C lagged behind in improvement between ages 21 and 23, further distinguishing them from CHR-NC (p < .001). A similar period of stagnation was apparent for role functioning, but to a lesser extent (p = .007). The results remained consistent when we accounted for the time to conversion. Our findings suggest that CHR-C start lagging behind CHR-NC in social and role functioning in adolescence, followed by a period of further stagnation in adulthood.

Indexed as

Social AdjustmentAdolescentChildFemaleHumansLongitudinal StudiesMalePsychotic DisordersYoung Adult

Identifiers

PMID28420458
PMCPMC5648633

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.