Evidence map›Paper›PMID 28420330›Full record

ArticleBMC neurology2017

Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report.

Yoshitsugu Nakamura, Hideto Nakajima, Hiroki Tani, Takafumi Hosokawa, Shimon Ishida, Fumiharu Kimura, Kimihiko Kaneko, Toshiyuki Takahashi, Ichiro Nakashima

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 69 citations in OpenAlex.

  1. Sequence Variation of Epstein-Barr Virus EBNA-1 Gene in Central Nervous System Inflammatory Demyelinating Diseases in Pakistan.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yoshitsugu NakamuraDivision of Neurology, Department of Internal Medicine IV, Osaka Medical College, Daigakumachi 2-7, Takatsukishi, Osaka, 569-8686, Japan. in1394@osaka-med.ac.jp.
Hideto NakajimaDivision of Neurology, Department of Internal Medicine IV, Osaka Medical College, Daigakumachi 2-7, Takatsukishi, Osaka, 569-8686, Japan.
Hiroki TaniDivision of Neurology, Department of Internal Medicine IV, Osaka Medical College, Daigakumachi 2-7, Takatsukishi, Osaka, 569-8686, Japan.
Takafumi HosokawaDivision of Neurology, Department of Internal Medicine IV, Osaka Medical College, Daigakumachi 2-7, Takatsukishi, Osaka, 569-8686, Japan.
Shimon IshidaDivision of Neurology, Department of Internal Medicine IV, Osaka Medical College, Daigakumachi 2-7, Takatsukishi, Osaka, 569-8686, Japan.
Fumiharu KimuraDivision of Neurology, Department of Internal Medicine IV, Osaka Medical College, Daigakumachi 2-7, Takatsukishi, Osaka, 569-8686, Japan.
Kimihiko KanekoDivision of Neurology, Tohoku University School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Toshiyuki TakahashiDivision of Neurology, NHO Yonezawa Hospital, Ozimisawa 26100-1, Yonezawashi, Yamagata, 992-1202, Japan.
Ichiro NakashimaDivision of Neurology, Tohoku University School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Osaka Medical and Pharmaceutical University · JPTohoku University · JPYonezawa Women's Junior College · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder. We present a patient who developed anti-MOG antibody-positive ADEM following infectious mononucleosis (IM) due to Epstein-Barr virus (EBV) infection. CASE PRESENTATION: A 36-year-old healthy man developed paresthesia of bilateral lower extremities and urinary retention 8 days after the onset of IM due to primary EBV infection. The MRI revealed the lesions in the cervical spinal cord, the conus medullaris, and the internal capsule. An examination of the cerebrospinal fluid revealed pleocytosis. Cell-based immunoassays revealed positivity for anti-MOG antibody with a titer of 1:1024 and negativity for anti-aquaporin-4 antibody. His symptoms quickly improved after steroid pulse therapy followed by oral betamethasone. Anti-MOG antibody titer at the 6-month follow-up was negative.

conclusionsThis case suggests that primary EBV infection would trigger anti-MOG antibody-positive ADEM. Adult ADEM patients can be positive for anti-MOG antibody, the titers of which correlate well with the neurological symptoms.

Indexed as

AdultAquaporin 4AutoantibodiesCervical CordEncephalomyelitis, Acute DisseminatedEpstein-Barr Virus InfectionsHumansInfectious MononucleosisInternal CapsuleLeukocytosisMagnetic Resonance ImagingMaleMyelin-Oligodendrocyte GlycoproteinSpinal CordAquaporin 4AutoantibodiesMyelin-Oligodendrocyte GlycoproteinAcute disseminate encephalomyelitisAntecedent infectionCase reportEpstein–Barr virusMyelin oligodendrocyte glycoproteinTransverse myelitis

Identifiers

PMID28420330
PMCPMC5395865
OpenAlexW2605685658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.