Evidence map›Paper›PMID 28420323›Full record

ArticleBMC neurology2017

Study protocol: Insight 46 - a neuroscience sub-study of the MRC National Survey of Health and Development.

Christopher A Lane, Thomas D Parker, Dave M Cash, Kirsty Macpherson, Elizabeth Donnachie, Heidi Murray-Smith, Anna Barnes, Suzie Barker, Daniel G Beasley, Jose Bras and 33 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. PET Image Reconstruction Using Deep Diffusion Image Prior.IEEE transactions on medical imaging · 2026
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  5. Location patterns and longitudinal progression of white matter hyperintensities.medRxiv : the preprint server for health sciences · 2026
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 6 institutions in 3 countries.

Christopher A LaneDementia Research Centre, Institute of Neurology, University College London, London, UK.
Thomas D ParkerDementia Research Centre, Institute of Neurology, University College London, London, UK.
Dave M CashDementia Research Centre, Institute of Neurology, University College London, London, UK.
Kirsty MacphersonDementia Research Centre, Institute of Neurology, University College London, London, UK.
Elizabeth DonnachieLeonard Wolfson Experimental Neurology Centre, Institute of Neurology, University College London, London, UK.
Heidi Murray-SmithDementia Research Centre, Institute of Neurology, University College London, London, UK.
Anna BarnesInstitute of Nuclear Medicine, University College London Hospitals, London, UK.
Suzie BarkerDementia Research Centre, Institute of Neurology, University College London, London, UK.
Daniel G BeasleyTranslational Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Jose BrasDepartment of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
David BrownInstitute of Nuclear Medicine, University College London Hospitals, London, UK.
Ninon BurgosTranslational Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Michelle ByfordMRC Unit for Lifelong Health and Ageing at UCL, London, UK.
M Jorge CardosoTranslational Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Ana CarvalhoInstitute of Nuclear Medicine, University College London Hospitals, London, UK.
Jessica CollinsDementia Research Centre, Institute of Neurology, University College London, London, UK.
Enrico De VitaLysholm Department of Neuroradiology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
John C DicksonInstitute of Nuclear Medicine, University College London Hospitals, London, UK.
Norah EpieDementia Research Centre, Institute of Neurology, University College London, London, UK.
Miklos EspakTranslational Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Susie M D HenleyDementia Research Centre, Institute of Neurology, University College London, London, UK.
Chandrashekar HoskoteLysholm Department of Neuroradiology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
Michael HutelDementia Research Centre, Institute of Neurology, University College London, London, UK.
Jana KlimovaDementia Research Centre, Institute of Neurology, University College London, London, UK.
Ian B MaloneDementia Research Centre, Institute of Neurology, University College London, London, UK.
Pawel MarkiewiczTranslational Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Andrew MelbourneTranslational Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Marc ModatDementia Research Centre, Institute of Neurology, University College London, London, UK.
Anette SchragDepartment of Clinical Neuroscience, Institute of Neurology, University College London, London, UK.
Sachit ShahLysholm Department of Neuroradiology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
Nikhil SharmaMRC Unit for Lifelong Health and Ageing at UCL, London, UK.
Carole H SudreDementia Research Centre, Institute of Neurology, University College London, London, UK.
David L ThomasLeonard Wolfson Experimental Neurology Centre, Institute of Neurology, University College London, London, UK.
Andrew WongMRC Unit for Lifelong Health and Ageing at UCL, London, UK.
Hui ZhangDepartment of Computer Science and Centre for Medical Image Computing, University College London, London, UK.
John HardyReta Lila Weston Research Laboratories, Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
Henrik ZetterbergDepartment of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
Sebastien OurselinTranslational Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Sebastian J CrutchDementia Research Centre, Institute of Neurology, University College London, London, UK.
Diana KuhMRC Unit for Lifelong Health and Ageing at UCL, London, UK.
Marcus RichardsMRC Unit for Lifelong Health and Ageing at UCL, London, UK.
Nick C FoxDementia Research Centre, Institute of Neurology, University College London, London, UK.
Jonathan M SchottDementia Research Centre, Institute of Neurology, University College London, London, UK. j.schott@ucl.ac.uk.
University College London · GBUK Dementia Research Institute · GBMRC Unit for Lifelong Health and Ageing · GBRoyal London Hospital · GBNational Hospital for Neurology and Neurosurgery · GBUniversity of Gothenburg · SE

Funding

Medical Research Council G0701075Medical Research Council G0901254Medical Research Council G1001253Medical Research Council MC_UU_12019/1Medical Research Council MC_UU_12019/3Medical Research Council MR/J004758/1Medical Research Council MR/J01107X/1Medical Research Council MR/K01417X/1Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2Medical Research Council MR/L501542/1Medical Research Council MR/M009106/1Parkinson's UK G-1307Wellcome Trust
6 · The paper itself

Abstract

backgroundIncreasing age is the biggest risk factor for dementia, of which Alzheimer's disease is the commonest cause. The pathological changes underpinning Alzheimer's disease are thought to develop at least a decade prior to the onset of symptoms. Molecular positron emission tomography and multi-modal magnetic resonance imaging allow key pathological processes underpinning cognitive impairment - including β-amyloid depostion, vascular disease, network breakdown and atrophy - to be assessed repeatedly and non-invasively. This enables potential determinants of dementia to be delineated earlier, and therefore opens a pre-symptomatic window where intervention may prevent the onset of cognitive symptoms. METHODS/

designThis paper outlines the clinical, cognitive and imaging protocol of "Insight 46", a neuroscience sub-study of the MRC National Survey of Health and Development. This is one of the oldest British birth cohort studies and has followed 5362 individuals since their birth in England, Scotland and Wales during one week in March 1946. These individuals have been tracked in 24 waves of data collection incorporating a wide range of health and functional measures, including repeat measures of cognitive function. Now aged 71 years, a small fraction have overt dementia, but estimates suggest that ~1/3 of individuals in this age group may be in the preclinical stages of Alzheimer's disease. Insight 46 is recruiting 500 study members selected at random from those who attended a clinical visit at 60-64 years and on whom relevant lifecourse data are available. We describe the sub-study design and protocol which involves a prospective two time-point (0, 24 month) data collection covering clinical, neuropsychological, β-amyloid positron emission tomography and magnetic resonance imaging, biomarker and genetic information. Data collection started in 2015 (age 69) and aims to be completed in 2019 (age 73). DISCUSSION: Through the integration of data on the socioeconomic environment and on physical, psychological and cognitive function from 0 to 69 years, coupled with genetics, structural and molecular imaging, and intensive cognitive and neurological phenotyping, Insight 46 aims to identify lifetime factors which influence brain health and cognitive ageing, with particular focus on Alzheimer's disease and cerebrovascular disease. This will provide an evidence base for the rational design of disease-modifying trials.

Indexed as

Early DiagnosisResearch DesignAgedAlzheimer DiseaseBiomarkersDementiaEnglandFemaleHumansMaleMiddle AgedScotlandBiomarkersEpidemiology, Life course, Genetics, Alzheimer’s Disease, Ageing, Magnetic resonance imaging, Positron emission tomography, Cognition, Vascular disease, Birth cohort

Identifiers

PMID28420323
PMCPMC5395844
OpenAlexW2605878539

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.