ArticleInternational journal of molecular sciences2017
Silk Fibroin-Alginate-Hydroxyapatite Composite Particles in Bone Tissue Engineering Applications In Vivo.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- A degradable hydrogel scaffold incorporating the LL-37 for gingival soft tissue regeneration.Regenerative biomaterials · 2026Article
- Structurally and functionally optimized silk fibroin-alginate-based biomimetic scaffolds reinforced with nanobioceramics for bone tissue engineering applications.Journal of nanobiotechnology · 2025Article
- Advances in the application and research of biomaterials in promoting bone repair and regeneration through immune modulation.Materials today. Bio · 2025Review
- Efficacy of a gelatin-based hemostatic sponge and hydroxyapatite-chitosan nanocomposites (nHAp/CS) on regeneration of radial bone defects in rabbits.Open veterinary journal · 2025Article
- The Application of Regenerated Silk Fibroin in Tissue Repair.Materials (Basel, Switzerland) · 2024Review
- Degradable Polymeric Bio(nano)materials and Their Biomedical Applications: A Comprehensive Overview and Recent Updates.Polymers · 2024Review
- Silk fibroin-based scaffolds for tissue engineering.Frontiers in bioengineering and biotechnology · 2024Review
- Advanced Applications of Silk-Based Hydrogels for Tissue Engineering: A Short Review.Biomimetics (Basel, Switzerland) · 2023Review
- A Comprehensive Review on Silk Fibroin as a Persuasive Biomaterial for Bone Tissue Engineering.International journal of molecular sciences · 2023Review
- Novel Approaches and Biomaterials for Bone Tissue Engineering: A Focus on Silk Fibroin.Materials (Basel, Switzerland) · 2022Review
- Multiple ways for the same destination: bone regeneration.Maxillofacial plastic and reconstructive surgery · 2022Review
- Extrusion Printed Silk Fibroin Scaffolds with Post-mineralized Calcium Phosphate as a Bone Structural Material.International journal of bioprinting · 2022Article
- Synthetic materials in craniofacial regenerative medicine: A comprehensive overview.Frontiers in bioengineering and biotechnology · 2022Review
- 3D Printing and Bioprinting to Model Bone Cancer: The Role of Materials and Nanoscale Cues in Directing Cell Behavior.Cancers · 2021Review
- Alginate and alginate composites for biomedical applications.Asian journal of pharmaceutical sciences · 2021Review
- How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?-Blending and Cross-Linking of Silk Fibroin-A Review.Materials (Basel, Switzerland) · 2021Review
- Histomorphometric, Immunohistochemical, Ultrastructural Characterization of a Nano-Hydroxyapatite/Beta-Tricalcium Phosphate Composite and a Bone Xenograft in Sub-Critical Size Bone Defect in Rat Calvaria.Materials (Basel, Switzerland) · 2020Article
- Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration.Biomolecules · 2019Review
- Osteogenic Differentiation of Mesenchymal Stem Cells with Silica-Coated Gold Nanoparticles for Bone Tissue Engineering.International journal of molecular sciences · 2019Article
- Biocompatibility and Biological Efficiency of Inorganic Calcium Filled Bacterial Cellulose Based Hydrogel Scaffolds for Bone Bioengineering.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the in vivo bone regeneration capability of alginate (AL), AL/hydroxyapatite (HA), and AL/HA/silk fibroin (SF) composites. Forty Sprague Dawley rats were used for the animal experiments. Central calvarial bone (diameter: 8.0 mm) defects were grafted with AL, AL/HA, or AL/HA/SF. New bone formation was evaluated by histomorphometric analysis. To demonstrate the immunocompatibility of each group, the level of tumor necrosis factor (TNF)-α expression was studied by immunohistochemistry (IHC) and quantitative reverse transcription polymerase chain reaction (qRT-PCR) at eight weeks post implantation. Additionally, osteogenic markers, such as fibroblast growth factor (FGF)-23, osteoprotegerin (OPG), and Runt-related transcription factor (Runx2) were evaluated by qPCR or IHC at eight weeks post implantation. The AL/HA/SF group showed significantly higher new bone formation than did the control group (
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