ArticleInternational journal of molecular sciences2017
Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Effects of meal timing on changes in circulating epinephrine, norepinephrine, and acylated ghrelin concentrations: a pilot study.Nutrition & diabetes · 2017Trial
- Autophagy in hypothalamic POMC and AgRP neurons: mechanisms and therapeutic implications for obesity.International journal of obesity (2005) · 2026Review
- GHSR suppression in neurons protects against aging-associated metabolic and cognitive impairments.GeroScience · 2026Article
- LEAP2 as a therapeutic target in obesity and cardiometabolic disorders.Reviews in endocrine & metabolic disorders · 2026Review
- Article
- GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male mice.Journal of neuroendocrinology · 2025Article
- Temporal control of eating and body weight by GHSR-expressing suprachiasmatic nucleus neurons.Cell reports · 2025Article
- The Coding Logic of Interoception.Annual review of physiology · 2024Review
- Ghrelin-responsive mediobasal hypothalamic neurons mediate exercise-associated food intake and exercise endurance.JCI insight · 2023Article
- Article
- CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake.Nature metabolism · 2023Article
- CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst.Biology of sex differences · 2023Article
- The expression and function of growth hormone secretagogue receptor in immune cells: A current perspective.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Deletion of ghrelin alters tryptophan metabolism and exacerbates experimental ulcerative colitis in aged mice.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Arcuate Nucleus-Dependent Regulation of Metabolism-Pathways to Obesity and Diabetes Mellitus.Endocrine reviews · 2022Review
- "Sibling" battle or harmony: crosstalk between nesfatin-1 and ghrelin.Cellular and molecular life sciences : CMLS · 2022Review
- Neuronal GHS-R Differentially Modulates Feeding Patterns under Normal and Obesogenic Conditions.Biomolecules · 2022Article
- Ghrelin treatment induces rapid and delayed increments of food intake: a heuristic model to explain ghrelin's orexigenic effects.Cellular and molecular life sciences : CMLS · 2021Article
- Effects of Growth Hormone Receptor Ablation in Corticotropin-Releasing Hormone Cells.International journal of molecular sciences · 2021Article
- Ghrelin-induced Food Intake, but not GH Secretion, Requires the Expression of the GH Receptor in the Brain of Male Mice.Endocrinology · 2021Article
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Authors and funding
13 authors.
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Abstract
Ghrelin, an orexigenic hormone released primarily from the gut, signals the hypothalamus to stimulate growth hormone release, enhance appetite and promote weight gain. The ghrelin receptor, aka Growth Hormone Secretagogue Receptor (GHS-R), is highly expressed in the brain, with highest expression in Agouti-Related Peptide (AgRP) neurons of the hypothalamus. We recently reported that neuron-specific deletion of GHS-R completely prevents diet-induced obesity (DIO) in mice by activating non-shivering thermogenesis. To further decipher the specific neuronal circuits mediating the metabolic effects of GHS-R, we generated AgRP neuron-specific GHS-R knockout mice (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.