Evidence map›Paper›PMID 28420041›Full record

ArticleSynapse (New York, N.Y.)2017

[

Patrick J Lao, Tobey J Betthauser, Dana L Tudorascu, Todd E Barnhart, Ansel T Hillmer, Charles K Stone, Jogeshwar Mukherjee, Bradley T Christian

Abstract read
In one paragraph

Article in Synapse (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Increased Binding of [Synapse (New York, N.Y.) · 2026
    Article
  2. Reduction in [Brain research · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. [Molecules (Basel, Switzerland) · 2021
    Article
  7. Article
  8. Human biodistribution and dosimetry of [Nuclear medicine and biology · 2017
    Article
  9. News and views on in-vivo imaging of neurotransmission using PET and MRI.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Patrick J LaoDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53705.ORCID 0000-0003-2243-3547
Tobey J BetthauserDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53705.
Dana L TudorascuDepartment of Medicine, Biostatistics, Psychiatry, and Clinical and Translational Science, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213.
Todd E BarnhartDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53705.
Ansel T HillmerDepartment of Radiology and Biomedical Imaging, and Psychiatry, Yale University, New Haven, Connecticut, 06520.
Charles K StoneDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, 53705.
Jogeshwar MukherjeeDepartment of Radiological Sciences, University of California-Irvine, Irvine, California, 92697.
Bradley T ChristianDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53705.

Funding

Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 2016 to 2020
$6.0M
PET Imaging Agents for Nicotinic a4b2 ReceptorsR01AG029479 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MUKHERJEE, JOGESHWAR · 2007 to 2017
$2.6M
PET Imaging agents for a4b2 Nicotinic ReceptorsRF1AG029479 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHRISTIAN, BRADLEY T, MUKHERJEE, JOGESHWAR · 2019 to 2020
$2.2M
NIA NIH HHS R01 AG029479NIA NIH HHS RF1 AG029479NICHD NIH HHS U54 HD090256
6 · The paper itself

Abstract

The aim of this study was to examine the suitability of [

methodsEight healthy subjects (4 M,4 F;21-69,44 ± 21 yrs) underwent a [

resultsThe DVR ranged from 1.3 to 2.5 across brain regions with a TRV of 0-7%, and did not demonstrate a systematic difference between test and retest. The ICCs ranged from 0.2 to 0.9. DVR estimates were stable after 40 min.

conclusionThe binding profile and tracer kinetics of [

Indexed as

Fluorine RadioisotopesPositron-Emission TomographyPyridinesPyrrolesRadiopharmaceuticalsAdultAgedBrainBrain MappingFemaleHumansKineticsMagnetic Resonance ImagingMaleMiddle AgedProtein BindingFluorine Radioisotopesnicotinic receptor alpha4beta2nifenePyridinesPyrrolesRadiopharmaceuticalsReceptors, Nicotinicfirst-in-humanspositron emission tomographyα4β2

Identifiers

PMID28420041
PMCPMC5541262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.