Evidence map›Paper›PMID 28419644›Full record

ArticleJournal of magnetic resonance imaging : JMRI2018

Diffusion-weighted imaging of hyperpolarized [

Irene Marco-Rius, Jeremy W Gordon, Aras N Mattis, Robert Bok, Romelyn Delos Santos, Subramanian Sukumar, Peder E Z Larson, Daniel B Vigneron, Michael A Ohliger

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Hyperpolarized carbon 13 MRI in liver diseases: Recent advances and future opportunities.Liver international : official journal of the International Association for the Study of the Liver · 2022
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Irene Marco-RiusDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0001-5076-8526
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Aras N MattisDepartment of Pathology, University of California San Francisco, San Francisco, California, USA.
Robert BokDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Romelyn Delos SantosDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Subramanian SukumarDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Michael A OhligerDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
University of California, San Francisco · US

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John Kurhanewicz · 2011 to 2026
$19.9M
Hyperpolarized C-13 Diffusion MRI Measures of Cellular Transport and MetabolismR01EB016741 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL · 2014 to 2017
$2.0M
Regulation of Lipid Metabolism by miR-29a within HepatocytesK08DK098270 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTIS, ARAS NIKODEMAS · 2013 to 2017
$789k
NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R01 EB016741NIDDK NIH HHS K08 DK098270NIDDK NIH HHS L30 DK089949NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

purposeTo compare the apparent diffusion coefficient (ADC) of hyperpolarized (HP) [ MATERIALS AND

methodsADC measurements for water and [

resultsIn cell-free phantoms with 12.5% agarose, water ADC was nearly twice the ADC of urea (1.93 × 10

conclusionADC of injected hyperpolarized urea in healthy liver reflects a smaller change as compared to free solution than ADC of water. This may reflect differences in cellular compartmentalization of the two compounds. No significant change in ADC of either water or urea were observed in relatively mild stages of liver fibrosis. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:141-151.

Indexed as

Diffusion Magnetic Resonance ImagingPhantoms, ImagingAnimalsCarbon IsotopesCell-Free SystemLiverLiver CirrhosisMaleMiceReproducibility of ResultsSepharoseUreaWaterCarbon-13Carbon IsotopesSepharoseUreaWaterapparent diffusion coefficientcarbon tetrachloridedynamic nuclear polarizationhyperpolarizationmouse liverMRI

Identifiers

PMID28419644
PMCPMC5645231
OpenAlexW2605775057

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.