ArticleBritish journal of clinical pharmacology2017
A general empirical model for renal drug handling in pharmacokinetic analyses.
Article in British journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- The intact nephron hypothesis as a model for renal drug handling.European journal of clinical pharmacology · 2019Pooled it
- A population pharmacokinetic model of intravenous telavancin in healthy individuals to assess tissue exposure.Naunyn-Schmiedeberg's archives of pharmacology · 2019Trial
- Modeling Metformin and Dapagliflozin Pharmacokinetics in Chronic Kidney Disease.The AAPS journal · 2024Article
- Predicting the Effect of Renal Function on Systemic Clearance: Is a Simple Scaling Method Sufficient?Journal of pharmaceutical sciences · 2023Article
- Population pharmacokinetics of lenalidomide in patients with B-cell malignancies.British journal of clinical pharmacology · 2019Article
- A general empirical model for renal drug handling in pharmacokinetic analyses.British journal of clinical pharmacology · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
Dose adjustment in renal insufficiency is generally based on the assumption that renal drug clearance is related linearly to glomerular filtration rate. The theory underpinning this model is the intact nephron hypothesis, which says that impaired renal function is caused by a reduction in the number of complete (intact) nephrons. The purpose of the present commentary is to propose a general empirical model for renal drug handling. We will explore models for renal function under two scenarios: one that aligns with the intact nephron hypothesis, and one that relaxes the assumptions of this hypothesis. We propose that a nonlinear, non-intact nephron model will allow for differences in renal drug handling, while incorporating the intact nephron hypothesis model as a special case.
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