Evidence map›Paper›PMID 28419519›Full record

ArticleJournal of cellular biochemistry2017

Deletion of a Distal RANKL Gene Enhancer Delays Progression of Atherosclerotic Plaque Calcification in Hypercholesterolemic Mice.

Sohel Shamsuzzaman, Melda Onal, Hillary C St John, J Wesley Pike

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sohel ShamsuzzamanDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706.
Melda OnalDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706.ORCID 0000-0002-5804-495X
Hillary C St JohnDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706.
J Wesley PikeDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706.
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Molecular Mechanisms of RANKL Activation in OsteoblastsR01DK074993 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 2007 to 2017
$4.0M
BONE CELL REGULATION OF THE VITAMIN D RECEPTOR GENER01AR045173 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 1999 to 2015
$3.5M
NCI NIH HHS P30 CA014520NIAMS NIH HHS R01 AR045173NIDDK NIH HHS R01 DK074993
6 · The paper itself

Abstract

Receptor activator of NF-κB ligand (RANKL) is a TNF-like cytokine which mediates diverse physiological functions including bone remodeling and immune regulation. RANKL has been identified in atherosclerotic lesions; however, its role in atherosclerotic plaque development remains elusive. An enhancer located 75 kb upstream of the murine Rankl gene's transcription start site designated D5 is important for its calciotropic hormone- and cytokine-mediated expression. Here, we determined the impact of RANKL levels in atherosclerotic plaque development in the D5 enhancer-null (D5

Indexed as

Enhancer Elements, GeneticSequence DeletionAnimalsBase SequenceCalcinosisDiet, High-FatDisease Models, AnimalDisease ProgressionFemaleHypercholesterolemiaMiceMice, KnockoutPlaque, AtheroscleroticRANK LigandRANK LigandTnfsf11 protein, mouseATHEROSCLEROTIC PLAQUEDISTAL ENHANCERGENE REGULATIONPLAQUE CALCIFICATIONPLAQUE RANKLRANKLµCT

Identifiers

PMID28419519
PMCPMC5645213
OpenAlexW2606712773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.