Evidence map›Paper›PMID 28419337›Full record

ArticleNeurosurgery2018

Targeted Embolization of Aneurysms Associated With Brain Arteriovenous Malformations at High Risk for Surgical Resection: A Case-Control Study.

Matthew D Alexander, Daniel S Hippe, Daniel L Cooke, Danial K Hallam, Steven W Hetts, Helen Kim, Michael T Lawton, Laligam N Sekhar, Louis J Kim, Basavaraj V Ghodke

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Neuro-interventional Radiology in Paediatric Patients: An Update.Cardiovascular and interventional radiology · 2025
    Review
  3. Review
  4. N-butyl Cyanoacrylate Use in Various Neuroendovascular Diseases.Journal of neuroendovascular therapy · 2025
    Review
  5. Review
  6. Article
  7. Single-center experience with endovascular treatment of cerebral arteriovenous malformations with intent to cure in pediatric patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022
    Article
  8. Review
  9. Observational
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Matthew D AlexanderUniversity of California San Francisco, Department of Radiology and Biomedical Imaging, San Francisco, California.
Daniel S HippeUni-versity Washington, Department of Radiology, Seattle, Washington.
Daniel L CookeUniversity of California San Francisco, Department of Radiology and Biomedical Imaging, San Francisco, California.
Danial K HallamUni-versity Washington, Department of Radiology, Seattle, Washington.
Steven W HettsUniversity of California San Francisco, Department of Radiology and Biomedical Imaging, San Francisco, California.
Helen KimUniver-sity of California San Francisco, Depart-ment of Anesthesia and Perioperative Care, San Francisco, California.
Michael T LawtonUniversity of California San Francisco, Department of Neurological Surgery, San Francisco, California.
Laligam N SekharUniversity Washington, De-partment of Neurological Surgery, Seattle, Washington.
Louis J KimUniversity Washington, De-partment of Neurological Surgery, Seattle, Washington.
Basavaraj V GhodkeUni-versity Washington, Department of Radiology, Seattle, Washington.
Neurological Surgery · USUniversity of California, San Francisco · US

Funding

PREDICTORS OF SPONTANEOUS CEREBRAL AVM HEMORRHAGER01NS034949 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIM, HELEN · 1995 to 2017
$6.5M
NINDS NIH HHS R01 NS034949
6 · The paper itself

Abstract

backgroundHigh-risk components of brain arteriovenous malformations (BAVMs) can be targeted to reduce the risk of lesion rupture.

objectiveTo evaluate targeted embolization of aneurysms against other means of treatment with a case-control analysis; we previously investigated this approach associated with BAVMs.

methodsRetrospective analysis of patients with BAVMs was performed, identifying patients treated with intention to occlude only an aneurysm associated with a BAVM. For each targeted aneurysm embolization (TAE) patient identified, 4 control patients were randomly selected, controlling for rupture status, age, and Spetzler-Martin plus Lawton-Young supplemental score. Analysis was performed to compare rates of adverse events (hemorrhage, new seizure, and death) between the 2 groups.

resultsThirty-two patients met inclusion criteria, and 128 control patients were identified, out of 1103 patients treated during the study period. Thirty-four adverse events occurred (15 ruptures, 15 new seizures, and 11 deaths) during the follow-up period (mean 1157 d for the TAE cohort and 1036 d for the non-TAE cohort). Statistically lower associations were noted for the TAE group for any adverse event (hazard ratio 0.28, P = .037) and the composite outcome of hemorrhage or new seizure (hazard ratio 0.20, P = .029).

conclusionFor BAVMs at high risk for surgical resection, TAE can be performed safely and effectively. Patients treated with TAE had better outcomes than matched patients undergoing other combinations of treatment. TAE can be considered for BAVMs with high operative risk prior to radiosurgery or when no other treatment options are available.

Indexed as

AdultAgedCase-Control StudiesCohort StudiesEmbolization, TherapeuticFemaleFollow-Up StudiesHumansIntracranial AneurysmIntracranial Arteriovenous MalformationsMaleMiddle AgedPostoperative ComplicationsRadiosurgeryRandom AllocationRetrospective Studies

Identifiers

PMID28419337
PMCPMC5640504
OpenAlexW2606187978

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.