Evidence map›Paper›PMID 28419203›Full record

ArticleAmerican journal of epidemiology2017

Selective Cutoff Reporting in Studies of Diagnostic Test Accuracy: A Comparison of Conventional and Individual-Patient-Data Meta-Analyses of the Patient Health Questionnaire-9 Depression Screening Tool.

Brooke Levis, Andrea Benedetti, Alexander W Levis, John P A Ioannidis, Ian Shrier, Pim Cuijpers, Simon Gilbody, Lorie A Kloda, Dean McMillan, Scott B Patten and 18 more

Abstract read
In one paragraph

Article in American journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Brooke Levis
Andrea Benedetti
Alexander W Levis
John P A Ioannidis
Ian Shrier
Pim Cuijpers
Simon Gilbody
Lorie A Kloda
Dean McMillan
Scott B Patten
Russell J Steele
Roy C Ziegelstein
Charles H Bombardier
Flavia de Lima Osório
Jesse R Fann
Dwenda Gjerdingen
Femke Lamers
Manote Lotrakul
Sonia R Loureiro
Bernd Löwe
Juwita Shaaban
Lesley Stafford
Henk C P M van Weert
Mary A Whooley
Linda S Williams
Karin A Wittkampf
Albert S Yeung
Brett D Thombs

Funding

Obesity and Energy Metabolism CoreP30DK050456 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BERNLOHR, DAVID A · 1995 to 2015
$17.0M
CONTROLLED TRIAL OF SERTRALINE FOR DEPRESSION AFTER TBIR01HD039415 · NICHD · UNIVERSITY OF WASHINGTON · PI BOMBARDIER, CHARLES HENRY · 2000 to 2004
$2.6M
THE TREATMENT OF EATING DISORDERSK02MH065919 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CROW, SCOTT J · 2003 to 2007
$689k
Stepped Care Treatment of Postpartum DepressionR34MH072925 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GJERDINGEN, DWENDA K. · 2005 to 2007
$489k
NICHD NIH HHS R01 HD039415NIDDK NIH HHS P30 DK050456NIMH NIH HHS K02 MH065919NIMH NIH HHS R34 MH072925
6 · The paper itself

Abstract

In studies of diagnostic test accuracy, authors sometimes report results only for a range of cutoff points around data-driven "optimal" cutoffs. We assessed selective cutoff reporting in studies of the diagnostic accuracy of the Patient Health Questionnaire-9 (PHQ-9) depression screening tool. We compared conventional meta-analysis of published results only with individual-patient-data meta-analysis of results derived from all cutoff points, using data from 13 of 16 studies published during 2004-2009 that were included in a published conventional meta-analysis. For the "standard" PHQ-9 cutoff of 10, accuracy results had been published by 11 of the studies. For all other relevant cutoffs, 3-6 studies published accuracy results. For all cutoffs examined, specificity estimates in conventional and individual-patient-data meta-analyses were within 1% of each other. Sensitivity estimates were similar for the cutoff of 10 but differed by 5%-15% for other cutoffs. In samples where the PHQ-9 was poorly sensitive at the standard cutoff, authors tended to report results for lower cutoffs that yielded optimal results. When the PHQ-9 was highly sensitive, authors more often reported results for higher cutoffs. Consequently, in the conventional meta-analysis, sensitivity increased as cutoff severity increased across part of the cutoff range-an impossibility if all data are analyzed. In sum, selective reporting by primary study authors of only results from cutoffs that perform well in their study can bias accuracy estimates in meta-analyses of published results.

Indexed as

Epidemiologic MethodsMeta-Analysis as TopicBiasData AccuracyDepressionDiagnostic Techniques and ProceduresHumansSensitivity and Specificitybiasdepressiondiagnostic test accuracyindividual-patient-data meta-analysismeta-analysisscreeningselective cutoff reporting

Identifiers

PMID28419203
PMCPMC5430941

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.