Evidence map›Paper›PMID 28419082›Full record

ReviewPediatric research2017

Diffuse optical tomography to investigate the newborn brain.

Chuen Wai Lee, Robert J Cooper, Topun Austin

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05514665 (A Prospective Feasibility Study to Derive Novel Imaging Biomarker of Perinatal Brain Injury Based on Bedside Diffuse Optical Tomography in Neonates), which is not on this map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05514665 unknown statusnot on this mapstarted 2024, after this paper: background citation

A Prospective Feasibility Study to Derive Novel Imaging Biomarker of Perinatal Brain Injury Based on Bedside Diffuse Optical Tomography in Neonates

TypeobservationalSponsorHamilton Health Sciences CorporationRan2024 to 2026Enrolled25ConditionsHypoxia Ischemia, Cerebral, Hypoxia-Ischemia, Brain, Hypoxia Neonatal, Hypoxic-Ischemic EncephalopathyArmsDiffuse Optical Tomography
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 64 citations in OpenAlex.

  1. Advances in Wearable Bioimaging.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
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  17. Neonatal NIRS monitoring: recommendations for data capture and review of analytics.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Chuen Wai LeeneoLAB, The Evelyn Perinatal Imaging Centre, The Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Robert J CooperneoLAB, The Evelyn Perinatal Imaging Centre, The Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Topun AustinneoLAB, The Evelyn Perinatal Imaging Centre, The Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Cambridge University Hospitals NHS Foundation Trust · GBRosie Hospital · GBUniversity College London · GB

Funding

Medical Research Council MR/L017490/1
6 · The paper itself

Abstract

Over the past 15 years, functional near-infrared spectroscopy (fNIRS) has emerged as a powerful technology for studying the developing brain. Diffuse optical tomography (DOT) is an extension of fNIRS that combines hemodynamic information from dense optical sensor arrays over a wide field of view. Using image reconstruction techniques, DOT can provide images of the hemodynamic correlates to neural function that are comparable to those produced by functional magnetic resonance imaging. This review article explains the principles of DOT, and highlights the growing literature on the use of DOT in the study of healthy development of the infant brain, and the study of novel pathophysiology in infants with brain injury. Current challenges, particularly around instrumentation and image reconstruction, will be discussed, as will the future of this growing field, with particular focus on whole-brain, time-resolved DOT.

Indexed as

BrainElectroencephalographyHumansInfant, NewbornSpectroscopy, Near-InfraredTomography, Optical

Identifiers

PMID28419082
OpenAlexW2605734864

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.