ArticleOncotarget2017
Metastasis-associated protein 3 in colorectal cancer determines tumor recurrence and prognosis.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- MTA1 Regulates EMT and BRAF Signaling Networks in Canine Urothelial Carcinoma.International journal of molecular sciences · 2026Article
- Immunohistochemical Expression of Metastasis-Associated Gene 3 (MTA3) and Epithelial-Mesenchymal Transition (EMT) Markers in Colorectal Carcinoma: A Cross-sectional Study.Iranian journal of pathology · 2026Article
- Clinical value of the novel inflammatory-nutritional marker PALR in predicting early postoperative recurrence of colorectal cancer.Discover oncology · 2025Article
- Mechanisms of MTA3 in cancer and related diseases and its clinical applications.Frontiers in oncology · 2025Review
- Prognostic and immunological significance of metastasis-associated protein 3 in patients with thymic epithelial tumors.Discover oncology · 2024Article
- Article
- Metastasis-associated protein 1 promotes epithelial-mesenchymal transition in idiopathic pulmonary fibrosis by up-regulating Snail expression.Journal of cellular and molecular medicine · 2020Article
- A network-based predictive gene expression signature for recurrence risks in stage II colorectal cancer.Cancer medicine · 2020Article
- Longitudinal study of leukocyte DNA methylation and biomarkers for cancer risk in older adults.Biomarker research · 2019Article
- MTA3-SOX2 Module Regulates Cancer Stemness and Contributes to Clinical Outcomes of Tongue Carcinoma.Frontiers in oncology · 2019Article
- Prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer from multiple centers in China.World journal of gastroenterology · 2017Article
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Authors and funding
9 authors.
Funding
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Abstract
Metastasis-associated protein family (MTA) promotes tumor cell invasion and metastasis of human malignancies. However, the novel component of MTA family, MTA3 was found to play conflicting roles in human malignancies. While the expression pattern and potential function of MTA3 in colorectal cancer has not been addressed yet. In the present study, we investigated the protein expression of MTA3 by immunohistochemistry assay, analyzed its association with tumor progression, recurrence and prognosis in239 cases of patients. Results showed that MTA3 expression in colorectal cancer was significantly decreased in colorectal cancer compared with normal specimens. Its expression was found to be correlated with tumor differentiation, metastases and TNM stage. Kaplan-Meier analysis proved that MTA3 was associated with both disease-free survival and overall survival of patients with colorectal cancer that patients with negative MTA3 expression tend to have unfavorable outcome. Moreover, cox's proportional hazards analysis showed that negative MTA3 expression was an independent prognostic marker of poor outcome. These results provided the first evidence that MTA3 level was decreased in colorectal cancer and significantly correlated with tumor cell invasion and metastasis. It also demonstrated that MTA3 might serve as a potential marker of tumor recurrence and prognosis of colorectal cancer.
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