ArticleEmerging infectious diseases2017
Increased Neurotropic Threat from Burkholderia pseudomallei Strains with a B. mallei-like Variation in the bimA Motility Gene, Australia.
Article in Emerging infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Characterization of an isogenicInfection and immunity · 2026Article
- Genetic variation, structural analysis, and virulence implications of BimA and BimC in clinical isolates of Burkholderia pseudomallei in Thailand.Scientific reports · 2024Article
- Virulence of Burkholderia pseudomallei ATS2021 Unintentionally Imported to United States in Aromatherapy Spray.Emerging infectious diseases · 2024Article
- Review
- Article
- Cycle-Inhibiting Factor Is Associated withBiology · 2022Article
- Clinical Burkholderia pseudomallei isolates from north Queensland carry diverse bimABm genes that are associated with central nervous system disease and are phylogenomically distinct from other Australian strains.PLoS neglected tropical diseases · 2022Article
- Biogeography and genetic diversity of clinical isolates of Burkholderia pseudomallei in Sri Lanka.PLoS neglected tropical diseases · 2021Article
- Detection and differentiation of Burkholderia species with pathogenic potential in environmental soil samples.PloS one · 2021Article
- Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients.PLoS neglected tropical diseases · 2019Article
- Burkholderia pseudomallei-loaded cells act as a Trojan horse to invade the brain during endotoxemia.Scientific reports · 2018Article
- Melioidosis: An Australian Perspective.Tropical medicine and infectious disease · 2018Review
- Clinical Epidemiology of Septic Arthritis Caused byThe American journal of tropical medicine and hygiene · 2017Article
- Suspected cases of intracontinental Burkholderia pseudomallei sequence type homoplasy resolved using whole-genome sequencing.Microbial genomics · 2017Article
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10 authors at 2 institutions in 1 country.
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Abstract
Neurologic melioidosis is a serious, potentially fatal form of Burkholderia pseudomallei infection. Recently, we reported that a subset of clinical isolates of B. pseudomallei from Australia have heightened virulence and potential for dissemination to the central nervous system. In this study, we demonstrate that this subset has a B. mallei-like sequence variation of the actin-based motility gene, bimA. Compared with B. pseudomallei isolates having typical bimA alleles, isolates that contain the B. mallei-like variation demonstrate increased persistence in phagocytic cells and increased virulence with rapid systemic dissemination and replication within multiple tissues, including the brain and spinal cord, in an experimental model. These findings highlight the implications of bimA variation on disease progression of B. pseudomallei infection and have considerable clinical and public health implications with respect to the degree of neurotropic threat posed to human health.
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