Evidence map›Paper›PMID 28418811›Full record

ArticleRadiology2017

Hypertrabeculated Left Ventricular Myocardium in Relationship to Myocardial Function and Fibrosis: The Multi-Ethnic Study of Atherosclerosis.

Nadine Kawel-Boehm, Robyn L McClelland, Filip Zemrak, Gabriella Captur, W Gregory Hundley, Chia-Ying Liu, James C Moon, Steffen E Petersen, Bharath Ambale-Venkatesh, João A C Lima and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Highlights of the Virtual Society for Cardiovascular Magnetic Resonance 2022 Scientific Conference: CMR: improving cardiovascular care around the world.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Review
  7. Article
  8. Article
  9. Observational
  10. Article
  11. Left Ventricular Trabeculations in Athletes: Epiphenomenon or Phenotype of Disease?Current treatment options in cardiovascular medicine · 2018
    Review
  12. Fractal analysis of left ventricular trabeculations is associated with impaired myocardial deformation in healthy Chinese.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nadine Kawel-BoehmFrom the Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Md (N.K., C.Y.L., D.A.B.); Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); William Harvey Research Institute and National Institute of Health Research Cardiovascular Biomedical Research Unit at Barts, Queen Mary University of London, London, England (F.Z., S.E.P.); Institute of Cardiovascular Science, University College London and The Barts Heart Centre, St. Bartholomew's Hospital, London, England (G.C., J.C.M.); Department of Internal Medicine, Division of Cardiology, Wake Forest University, Winston-Salem, NC (W.G.H.); Department of Radiology (B.A.) and Department of Medicine, Division of Cardiology (J.A.C.L.), Johns Hopkins University, Baltimore, Md.
Robyn L McClellandFrom the Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Md (N.K., C.Y.L., D.A.B.); Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); William Harvey Research Institute and National Institute of Health Research Cardiovascular Biomedical Research Unit at Barts, Queen Mary University of London, London, England (F.Z., S.E.P.); Institute of Cardiovascular Science, University College London and The Barts Heart Centre, St. Bartholomew's Hospital, London, England (G.C., J.C.M.); Department of Internal Medicine, Division of Cardiology, Wake Forest University, Winston-Salem, NC (W.G.H.); Department of Radiology (B.A.) and Department of Medicine, Division of Cardiology (J.A.C.L.), Johns Hopkins University, Baltimore, Md.
Filip ZemrakFrom the Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Md (N.K., C.Y.L., D.A.B.); Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); William Harvey Research Institute and National Institute of Health Research Cardiovascular Biomedical Research Unit at Barts, Queen Mary University of London, London, England (F.Z., S.E.P.); Institute of Cardiovascular Science, University College London and The Barts Heart Centre, St. Bartholomew's Hospital, London, England (G.C., J.C.M.); Department of Internal Medicine, Division of Cardiology, Wake Forest University, Winston-Salem, NC (W.G.H.); Department of Radiology (B.A.) and Department of Medicine, Division of Cardiology (J.A.C.L.), Johns Hopkins University, Baltimore, Md.
Gabriella CapturFrom the Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Md (N.K., C.Y.L., D.A.B.); Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); William Harvey Research Institute and National Institute of Health Research Cardiovascular Biomedical Research Unit at Barts, Queen Mary University of London, London, England (F.Z., S.E.P.); Institute of Cardiovascular Science, University College London and The Barts Heart Centre, St. Bartholomew's Hospital, London, England (G.C., J.C.M.); Department of Internal Medicine, Division of Cardiology, Wake Forest University, Winston-Salem, NC (W.G.H.); Department of Radiology (B.A.) and Department of Medicine, Division of Cardiology (J.A.C.L.), Johns Hopkins University, Baltimore, Md.
W Gregory HundleyFrom the Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Md (N.K., C.Y.L., D.A.B.); Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); William Harvey Research Institute and National Institute of Health Research Cardiovascular Biomedical Research Unit at Barts, Queen Mary University of London, London, England (F.Z., S.E.P.); Institute of Cardiovascular Science, University College London and The Barts Heart Centre, St. Bartholomew's Hospital, London, England (G.C., J.C.M.); Department of Internal Medicine, Division of Cardiology, Wake Forest University, Winston-Salem, NC (W.G.H.); Department of Radiology (B.A.) and Department of Medicine, Division of Cardiology (J.A.C.L.), Johns Hopkins University, Baltimore, Md.
Chia-Ying LiuFrom the Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Md (N.K., C.Y.L., D.A.B.); Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); William Harvey Research Institute and National Institute of Health Research Cardiovascular Biomedical Research Unit at Barts, Queen Mary University of London, London, England (F.Z., S.E.P.); Institute of Cardiovascular Science, University College London and The Barts Heart Centre, St. Bartholomew's Hospital, London, England (G.C., J.C.M.); Department of Internal Medicine, Division of Cardiology, Wake Forest University, Winston-Salem, NC (W.G.H.); Department of Radiology (B.A.) and Department of Medicine, Division of Cardiology (J.A.C.L.), Johns Hopkins University, Baltimore, Md.
James C MoonFrom the Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Md (N.K., C.Y.L., D.A.B.); Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); William Harvey Research Institute and National Institute of Health Research Cardiovascular Biomedical Research Unit at Barts, Queen Mary University of London, London, England (F.Z., S.E.P.); Institute of Cardiovascular Science, University College London and The Barts Heart Centre, St. Bartholomew's Hospital, London, England (G.C., J.C.M.); Department of Internal Medicine, Division of Cardiology, Wake Forest University, Winston-Salem, NC (W.G.H.); Department of Radiology (B.A.) and Department of Medicine, Division of Cardiology (J.A.C.L.), Johns Hopkins University, Baltimore, Md.
Steffen E PetersenFrom the Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Md (N.K., C.Y.L., D.A.B.); Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); William Harvey Research Institute and National Institute of Health Research Cardiovascular Biomedical Research Unit at Barts, Queen Mary University of London, London, England (F.Z., S.E.P.); Institute of Cardiovascular Science, University College London and The Barts Heart Centre, St. Bartholomew's Hospital, London, England (G.C., J.C.M.); Department of Internal Medicine, Division of Cardiology, Wake Forest University, Winston-Salem, NC (W.G.H.); Department of Radiology (B.A.) and Department of Medicine, Division of Cardiology (J.A.C.L.), Johns Hopkins University, Baltimore, Md.
Bharath Ambale-VenkateshFrom the Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Md (N.K., C.Y.L., D.A.B.); Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); William Harvey Research Institute and National Institute of Health Research Cardiovascular Biomedical Research Unit at Barts, Queen Mary University of London, London, England (F.Z., S.E.P.); Institute of Cardiovascular Science, University College London and The Barts Heart Centre, St. Bartholomew's Hospital, London, England (G.C., J.C.M.); Department of Internal Medicine, Division of Cardiology, Wake Forest University, Winston-Salem, NC (W.G.H.); Department of Radiology (B.A.) and Department of Medicine, Division of Cardiology (J.A.C.L.), Johns Hopkins University, Baltimore, Md.
João A C LimaFrom the Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Md (N.K., C.Y.L., D.A.B.); Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); William Harvey Research Institute and National Institute of Health Research Cardiovascular Biomedical Research Unit at Barts, Queen Mary University of London, London, England (F.Z., S.E.P.); Institute of Cardiovascular Science, University College London and The Barts Heart Centre, St. Bartholomew's Hospital, London, England (G.C., J.C.M.); Department of Internal Medicine, Division of Cardiology, Wake Forest University, Winston-Salem, NC (W.G.H.); Department of Radiology (B.A.) and Department of Medicine, Division of Cardiology (J.A.C.L.), Johns Hopkins University, Baltimore, Md.
David A BluemkeFrom the Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Md (N.K., C.Y.L., D.A.B.); Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); William Harvey Research Institute and National Institute of Health Research Cardiovascular Biomedical Research Unit at Barts, Queen Mary University of London, London, England (F.Z., S.E.P.); Institute of Cardiovascular Science, University College London and The Barts Heart Centre, St. Bartholomew's Hospital, London, England (G.C., J.C.M.); Department of Internal Medicine, Division of Cardiology, Wake Forest University, Winston-Salem, NC (W.G.H.); Department of Radiology (B.A.) and Department of Medicine, Division of Cardiology (J.A.C.L.), Johns Hopkins University, Baltimore, Md.

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Molecular Biomedical Imaging Laboratory (NIBIB)ZIAEB000072 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI BLUEMKE, DAVID · 2010 to 2017
$5.0M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095163 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1999 to 2001
$443k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169
6 · The paper itself

Abstract

Purpose To determine if excess greater left ventricle (LV) trabeculation is associated with decreased average regional myocardial function, diffuse fibrosis, or both. Materials and Methods This was a HIPAA-compliant institutional board approved multicenter study, and all participants provided written informed consent. Participants in the Multi-Ethnic Study of Atherosclerosis (MESA) underwent a comprehensive cardiac magnetic resonance (MR) examination. LV trabeculation was measured with the maximal apical fractal dimension (FD), which is a marker of endocardial complexity. Demographic covariates, cardiovascular risk factors, and cardiac MR measurements were compared across quartiles of FD. Associations between FD and peak regional systolic circumferential strain (Ecc) and T1 time, a surrogate for diffuse myocardial fibrosis, were assessed with multivariable linear regression models. Results A total of 1123 subjects (593 [52.8%] female; mean age, 67.1 years ± 8.7 [standard deviation]) underwent FD and Ecc measurement, and 992 (521 [52.5%] female; mean age, 67.1 years ± 8.7) underwent FD and T1 measurement. Mean FD was 1.2 ± 0.07 in both groups, and mean Ecc was -18.3 ± 2.27 in the subjects who underwent FD and Ecc measurement. Global volumes and ejection fraction showed no differences between FD quartiles. However, with increasing FD quartile, Ecc was greater (indicating worse average regional function) (P < .001). After adjustment, greater trabeculation was associated with 21% worse myocardial strain (relative to the mean) per unit change in FD (regression coefficient = 4.0%; P < .001). There was no association between the degree of trabeculation and diffuse fibrosis measured with T1 mapping. Conclusion Average regional LV function was worse in individuals with greater LV trabeculation, supporting the concept of hypertrabeculation being an epiphenomenon of disease.

Indexed as

AgedAged, 80 and overAtherosclerosisCross-Sectional StudiesFemaleFibrosisHeartHeart VentriclesHumansMagnetic Resonance ImagingMaleMiddle AgedMyocardiumRacial GroupsUnited States

Identifiers

PMID28418811
PMCPMC5584648

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