ArticleRadiology2017
Relationship of Trochlear Morphology and Patellofemoral Joint Alignment to Superolateral Hoffa Fat Pad Edema on MR Images in Individuals with or at Risk for Osteoarthritis of the Knee: The MOST Study.
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Article in Radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19citing papers in PubMed, 1 pooled it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Osteoarthritic knees have a highly variable patellofemoral alignment: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Pooled it
- Reconstruction of normal morphology for simulated femoral condyle lesions based on shape statistical constraints and differential coordinate transformation.Medical & biological engineering & computing · 2026Article
- A novel assessment of the differences in various measurements in patients with patella alta and baja: a retrospective cross-sectional study.Quantitative imaging in medicine and surgery · 2024Article
- The association between patella alignment and morphology and knee osteoarthritis.Journal of orthopaedic surgery and research · 2024Article
- Association between quadriceps fat pad edema and patellofemoral osteoarthritis: a quantitative Q-Dixon-based magnetic resonance imaging (MRI) analysis.Quantitative imaging in medicine and surgery · 2024Article
- Superolateral Hoffa fat pad edema in adolescent competitive alpine skiers: temporal evolution over 4 years and risk factors.Insights into imaging · 2024Article
- Association among peripatellar fat pad edema and related patellofemoral maltracking parameters: a case-control magnetic resonance imaging study.BMC musculoskeletal disorders · 2023Article
- Article
- Predisposing factors for Hoffa's fat pad syndrome: a systematic review.Knee surgery & related research · 2023Review
- Magnetic Resonance Imaging-Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis.Arthritis care & research · 2022Article
- A quantitative MRI investigation of the association between iliotibial band syndrome and patellofemoral malalignment.Quantitative imaging in medicine and surgery · 2021Article
- Longitudinal analysis of the contribution of 3D patella and trochlear bone shape on patellofemoral joint osteoarthritic features.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Association of markers of patellofemoral maltracking to cartilage damage and bone marrow lesions on MRI: Data from the 2016 Olympic Games of Rio De Janeiro.European journal of radiology open · 2021Article
- Relation of Patellofemoral Joint Alignment, Morphology, and Radiographic Osteoarthritis to Frequent Anterior Knee Pain: Data from the Multicenter Osteoarthritis Study.Arthritis care & research · 2020Article
- Magnetic resonance imaging of impingement and friction syndromes around the knee.Skeletal radiology · 2020Review
- Sharp margin of antero-inferior lateral femoral condyle as a risk factor for patellar tendon-lateral femoral condyle friction syndrome.European radiology · 2020Article
- Quantitative Signal Intensity Alteration in Infrapatellar Fat Pad Predicts Incident Radiographic Osteoarthritis: The Osteoarthritis Initiative.Arthritis care & research · 2019Observational
- Article
- Is superolateral Hoffa's fat pad hyperintensity a marker of local patellofemoral joint disease? - The MOST study.Osteoarthritis and cartilage · 2017Article
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Authors and funding
11 authors at 1 institution in 2 countries.
Rafael WidjajahakimFrom the Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, 360 Huntington Ave, 301 Robinson Hall, Boston, MA 02115 (J.J.S.); the Clinical Epidemiology Research and Training Unit (R.W., T.N., D.T.F., J.J.S.) and Quantitative Imaging Center, Department of Radiology (M.R., M.J., F.W.R., A.G.), Boston University School of Medicine, Boston, Mass; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif (J.A.L.); Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Ala (C.E.L.); and Department of Epidemiology, University of Iowa, Iowa City, Iowa (J.C.T.).ORCID 0000-0002-9050-9454
Michael RouxFrom the Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, 360 Huntington Ave, 301 Robinson Hall, Boston, MA 02115 (J.J.S.); the Clinical Epidemiology Research and Training Unit (R.W., T.N., D.T.F., J.J.S.) and Quantitative Imaging Center, Department of Radiology (M.R., M.J., F.W.R., A.G.), Boston University School of Medicine, Boston, Mass; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif (J.A.L.); Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Ala (C.E.L.); and Department of Epidemiology, University of Iowa, Iowa City, Iowa (J.C.T.).
Mohamed JarrayaFrom the Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, 360 Huntington Ave, 301 Robinson Hall, Boston, MA 02115 (J.J.S.); the Clinical Epidemiology Research and Training Unit (R.W., T.N., D.T.F., J.J.S.) and Quantitative Imaging Center, Department of Radiology (M.R., M.J., F.W.R., A.G.), Boston University School of Medicine, Boston, Mass; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif (J.A.L.); Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Ala (C.E.L.); and Department of Epidemiology, University of Iowa, Iowa City, Iowa (J.C.T.).
Frank W RoemerFrom the Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, 360 Huntington Ave, 301 Robinson Hall, Boston, MA 02115 (J.J.S.); the Clinical Epidemiology Research and Training Unit (R.W., T.N., D.T.F., J.J.S.) and Quantitative Imaging Center, Department of Radiology (M.R., M.J., F.W.R., A.G.), Boston University School of Medicine, Boston, Mass; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif (J.A.L.); Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Ala (C.E.L.); and Department of Epidemiology, University of Iowa, Iowa City, Iowa (J.C.T.).
Tuhina NeogiFrom the Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, 360 Huntington Ave, 301 Robinson Hall, Boston, MA 02115 (J.J.S.); the Clinical Epidemiology Research and Training Unit (R.W., T.N., D.T.F., J.J.S.) and Quantitative Imaging Center, Department of Radiology (M.R., M.J., F.W.R., A.G.), Boston University School of Medicine, Boston, Mass; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif (J.A.L.); Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Ala (C.E.L.); and Department of Epidemiology, University of Iowa, Iowa City, Iowa (J.C.T.).
John A LynchFrom the Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, 360 Huntington Ave, 301 Robinson Hall, Boston, MA 02115 (J.J.S.); the Clinical Epidemiology Research and Training Unit (R.W., T.N., D.T.F., J.J.S.) and Quantitative Imaging Center, Department of Radiology (M.R., M.J., F.W.R., A.G.), Boston University School of Medicine, Boston, Mass; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif (J.A.L.); Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Ala (C.E.L.); and Department of Epidemiology, University of Iowa, Iowa City, Iowa (J.C.T.).
Cora E LewisFrom the Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, 360 Huntington Ave, 301 Robinson Hall, Boston, MA 02115 (J.J.S.); the Clinical Epidemiology Research and Training Unit (R.W., T.N., D.T.F., J.J.S.) and Quantitative Imaging Center, Department of Radiology (M.R., M.J., F.W.R., A.G.), Boston University School of Medicine, Boston, Mass; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif (J.A.L.); Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Ala (C.E.L.); and Department of Epidemiology, University of Iowa, Iowa City, Iowa (J.C.T.).
James C TornerFrom the Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, 360 Huntington Ave, 301 Robinson Hall, Boston, MA 02115 (J.J.S.); the Clinical Epidemiology Research and Training Unit (R.W., T.N., D.T.F., J.J.S.) and Quantitative Imaging Center, Department of Radiology (M.R., M.J., F.W.R., A.G.), Boston University School of Medicine, Boston, Mass; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif (J.A.L.); Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Ala (C.E.L.); and Department of Epidemiology, University of Iowa, Iowa City, Iowa (J.C.T.).
David T FelsonFrom the Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, 360 Huntington Ave, 301 Robinson Hall, Boston, MA 02115 (J.J.S.); the Clinical Epidemiology Research and Training Unit (R.W., T.N., D.T.F., J.J.S.) and Quantitative Imaging Center, Department of Radiology (M.R., M.J., F.W.R., A.G.), Boston University School of Medicine, Boston, Mass; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif (J.A.L.); Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Ala (C.E.L.); and Department of Epidemiology, University of Iowa, Iowa City, Iowa (J.C.T.).
Ali GuermaziFrom the Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, 360 Huntington Ave, 301 Robinson Hall, Boston, MA 02115 (J.J.S.); the Clinical Epidemiology Research and Training Unit (R.W., T.N., D.T.F., J.J.S.) and Quantitative Imaging Center, Department of Radiology (M.R., M.J., F.W.R., A.G.), Boston University School of Medicine, Boston, Mass; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif (J.A.L.); Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Ala (C.E.L.); and Department of Epidemiology, University of Iowa, Iowa City, Iowa (J.C.T.).
Joshua J StefanikFrom the Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, 360 Huntington Ave, 301 Robinson Hall, Boston, MA 02115 (J.J.S.); the Clinical Epidemiology Research and Training Unit (R.W., T.N., D.T.F., J.J.S.) and Quantitative Imaging Center, Department of Radiology (M.R., M.J., F.W.R., A.G.), Boston University School of Medicine, Boston, Mass; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif (J.A.L.); Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Ala (C.E.L.); and Department of Epidemiology, University of Iowa, Iowa City, Iowa (J.C.T.).
Boston University · US
Funding
Multicenter Osteoarthritis Study (MOST) Second RenewalU01AG019069 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL C · 2001 to 2020
$21.7MWORK DISABILITY-- PERSONS WITH RHEUMATOID ARTHRITISP60AR047785 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2016
$18.0MMulticenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical CenterU01AG018832 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A, TORNER, JAMES C · 2001 to 2020
$14.1MMulticenter Osteoarthritis Study (MOST) Second Renewal - Boston UniversityU01AG018820 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2019
$13.6MMulticenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical CenterU01AG018947 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2001 to 2020
$13.2MCentral Sensitization in Post-Knee Replacement Pain and Relation to OA PathologyR01AR062506 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NEOGI, TUHINA · 2012 to 2016
$2.4MThe Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and PainK24AR070892 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2017 to 2026
$1.1MNIAMS NIH HHS K24 AR070892NIAMS NIH HHS P60 AR047785NIAMS NIH HHS R01 AR062506NIA NIH HHS U01 AG018820NIA NIH HHS U01 AG018832NIA NIH HHS U01 AG018947NIA NIH HHS U01 AG019069
Abstract
Purpose To determine the relationship of patellofemoral joint alignment and trochlear morphology to superolateral Hoffa fat pad (SHFP) edema on magnetic resonance (MR) images in older adults with or at risk for osteoarthritis of the knee. Materials and Methods Institutional review board approval and written informed consent were obtained from all subjects. The Multicenter Osteoarthritis Study is a prospective cohort study of older adults with or at risk for osteoarthritis of the knee. Subjects were recruited from Birmingham, Alabama, and Iowa City, Iowa. In this cross-sectional study, patellofemoral joint alignment (bisect offset, patellar tilt angle, and Insall-Salvati ratio), trochlear morphology (sulcus angle, lateral and medial trochlear inclination, and trochlear angle) and SHFP edema were assessed on MR images of the knee. Measures of alignment and morphology were divided into quartiles, and SHFP was determined to be present or absent. Separate logistic regression models were used to determine the relationship of each measure of alignment and morphology to the presence of SHFP edema, with adjustments for age, sex, and body mass index. Results SHFP edema was present in 152 (13.4%) of the 1134 knees that were included. When compared with knees with measurements in the lowest quartile, knees with measurements in the highest quartile for trochlear angle, bisect offset, and Insall-Salvati ratios were 1.6 (95% confidence interval [CI]: 1.0, 2.6), 2.3 (95% CI: 1.3, 4.0), and 8.9 (95% CI: 4.7, 16.9) times more likely to show SHFP edema, respectively. No relationship was found between other measures and SHFP edema. Conclusion A more anterior trochlear facet, a more laterally displaced patella, and knees with patella alta were significantly associated with SHFP edema on MR images in subjects with or at risk for osteoarthritis of the knee.
Indexed as
Adipose TissueAgedAged, 80 and overCross-Sectional StudiesEdemaFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOsteoarthritis, KneePatellaPatellofemoral JointRisk
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