Evidence map›Paper›PMID 28418604›Full record

ArticleExperimental dermatology2017

Loss of INK4a/Arf gene enhances ultraviolet radiation-induced cutaneous tumor development.

Israr Ahmad, Purushotham Guroji, Amanda H DeBrot, Padma P Manapragada, Santosh K Katiyar, Craig A Elmets, Nabiha Yusuf

Open access · greenAbstract read
In one paragraph

Article in Experimental dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Oh, the Mutations You'll Acquire! A Systematic Overview of Cutaneous Squamous Cell Carcinoma.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2021
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Israr AhmadDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Purushotham GurojiDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Amanda H DeBrotDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Padma P ManapragadaDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Santosh K KatiyarDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Craig A ElmetsDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Nabiha YusufDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-5730-0037
University of Alabama at Birmingham · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Mechanisms elicited by type I interferons in cutaneous photocarcinogenesisR01AR071157 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YUSUF, NABIHA · 2016 to 2020
$1.8M
Topical Chemoprevention of Skin Cancer BiomarkersR01CA193885 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ELMETS, CRAIG A · 2016 to 2022
$1.7M
Photodermatological Effects of Toll Like Receptor-4 (TLR4)R03AR057483 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YUSUF, NABIHA · 2010 to 2011
$144k
Host Defense Mechanisms in Melanoma PathogenesisI01BX003395 · VA · BIRMINGHAM VA MEDICAL CENTER · PI ELMETS, CRAIG A · 2016 to 2019
–
BLRD VA I01 BX003395NCI NIH HHS P30 CA013148NCI NIH HHS R01 CA193885NIAMS NIH HHS R01 AR071157NIAMS NIH HHS R03 AR057483
6 · The paper itself

Abstract

The CDKN2A locus encodes for tumor suppressor genes p16

Indexed as

8-Hydroxy-2'-DeoxyguanosineAnimalsAntigens, LyCell NucleusCyclin-Dependent Kinase Inhibitor p16Cyclooxygenase 2CytoplasmDeoxyguanosineDinoprostoneFemaleInterleukin-1betaInterleukin-6MiceMice, KnockoutMyeloid CellsNF-KappaB Inhibitor alpha8-Hydroxy-2'-DeoxyguanosineAntigens, LyCdkn2a protein, mouseCyclin-Dependent Kinase Inhibitor p16Cyclooxygenase 2DeoxyguanosineDinoprostoneIL1B protein, mouseInterleukin-1betaInterleukin-6interleukin-6, mouseLy6G antigen, mouseNF-KappaB Inhibitor alphaReactive Oxygen SpeciesReceptors, Prostaglandin ERela protein, mouseTranscription Factor RelATumor Necrosis Factor-alphainflammationINK4a/Arfskin cancerultraviolet radiation

Identifiers

PMID28418604
PMCPMC5901725
OpenAlexW2605869577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.