ArticleJournal of biomechanical engineering2017
Tensile Mechanical Properties and Dynamic Collagen Fiber Re-Alignment of the Murine Cervix are Dramatically Altered Throughout Pregnancy.
Article in Journal of biomechanical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
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Who cites it
16 citing papers in PubMed.
- The Comparative Study of Cervical Shear Wave Elastography Between Twin and Singleton Pregnancy.International journal of women's health · 2020Trial
- Sex Hormones & Exercise in the Musculoskeletal System: From Signaling to Structure and Function.Endocrine reviews · 2026Article
- Collagen microarchitecture from polarized light imaging: a biomechanics perspective.Journal of biomedical optics · 2026Review
- Fatigue loading and volumetric microscopy demonstrate changes to the mouse cervix throughout and after pregnancy.Connective tissue research · 2025Article
- Effects of polydimethylsiloxane membrane surface treatments on human uterine smooth muscle cell strain response.Bioactive materials · 2024Article
- In vivo Raman spectroscopy monitors cervical change during labor.American journal of obstetrics and gynecology · 2022Article
- Mechanical Response of Mouse Cervices Lacking Decorin and Biglycan During Pregnancy.Journal of biomechanical engineering · 2022Article
- Heterogeneous microstructural changes of the cervix influence cervical funneling.Acta biomaterialia · 2022Article
- Hyperelastic Ex Vivo Cervical Tissue Mechanical Characterization.Sensors (Basel, Switzerland) · 2020Article
- Pregnancy-associated changes in cervical noncoding RNA.Epigenomics · 2020Article
- Mechanics of cervical remodelling: insights from rodent models of pregnancy.Interface focus · 2019Review
- Engineering and women's health: a slow start, but gaining momentum.Interface focus · 2019Review
- Evaluating residual strain throughout the murine female reproductive system.Journal of biomechanics · 2019Article
- The mechanical response of the mouse cervix to tensile cyclic loading in term and preterm pregnancy.Acta biomaterialia · 2018Article
- Common Cervicovaginal Microbial Supernatants Alter Cervical Epithelial Function: Mechanisms by WhichFrontiers in microbiology · 2018Article
- Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The cervix is a unique organ able to dramatically change its shape and function by serving as a physical barrier for the growing fetus and then undergoing dramatic dilation allowing for delivery of a term infant. As a result, the cervix endures changing mechanical forces from the growing fetus. There is an emerging concept that the cervix may change or remodel "early" in many cases of spontaneous preterm birth (sPTB). However, the mechanical role of the cervix in both normal and preterm birth remains unclear. Therefore, the primary objective of this study was to determine the mechanical and structural responses of murine cervical tissue throughout a normal gestational time course. In this study, both tissue structural and material properties were determined via a quasi-static tensile load-to-failure test, while simultaneously obtaining dynamic collagen fiber re-alignment via cross-polarization imaging. This study demonstrated that the majority of the mechanical properties evaluated decreased at midgestation and not just at term, while collagen fiber re-alignment occurred earlier in the loading curve for cervices at term. This suggests that although structural changes in the cervix occur throughout gestation, the differences in material properties function in combination with collagen fiber re-alignment as mechanical precursors to regulate term gestation. This work lays a foundation for investigating cervical biomechanics and the role of the cervix in preterm birth.
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Registered trials
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