Trial reportTranslational psychiatry2017
Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women.
Trial report in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Tri-Phasic Model ofOxytocin (TRIO): A systematic conceptual review of oxytocin-related ERP research.Biological psychology · 2020Pooled it
- Oxytocin Effects on Food Stimulus Processing and Food Intake in Females With or Without Binge Eating Disorder.The International journal of eating disorders · 2026Trial
- Effects of four-week intranasal oxytocin administration on large-scale brain networks in older adults.Neuropharmacology · 2024Trial
- Age-dependent effects of oxytocin in brain regions enriched with oxytocin receptors.Psychoneuroendocrinology · 2024Trial
- Oxytocinergic modulation of speech production-a double-blind placebo-controlled fMRI study.Social cognitive and affective neuroscience · 2023Trial
- Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men.Scientific reports · 2023Trial
- Intranasal oxytocin modulates the salience network in aging.NeuroImage · 2022Trial
- Oxytocin modulates local topography of human functional connectome in healthy men at rest.Communications biology · 2021Trial
- Oxytocin modulates the effective connectivity between the precuneus and the dorsolateral prefrontal cortex.European archives of psychiatry and clinical neuroscience · 2020Trial
- Intranasal oxytocin modulates brain responses to voice-identity recognition in typically developing individuals, but not in ASD.Translational psychiatry · 2020Trial
- Oxytocin Enhances an Amygdala Circuit Associated With Negative Symptoms in Schizophrenia: A Single-Dose, Placebo-Controlled, Crossover, Randomized Control Trial.Schizophrenia bulletin · 2020Trial
- Effects of oxytocin administration on salivary sex hormone levels in autistic and neurotypical women.Molecular autism · 2020Trial
- Oxytocin modulates the temporal dynamics of resting EEG networks.Scientific reports · 2019Trial
- Pleiotropic effects of oxytocin receptor polymorphisms: influencing striatocortical connectivity in bipolar disorder.International journal of bipolar disorders · 2025Article
- Neural connectivity of oxytocin receptor-expressing neurons in the nucleus accumbens and their role in social attachment.Hormones and behavior · 2025Article
- How does oxytocin modulate human behavior?Molecular psychiatry · 2025Review
- Endogenous Oxytocin and Depressive Symptoms in Drug Abstainers: The Roles of Perceived Social Support and Drug Abstinence Self-Efficacy.Psychology research and behavior management · 2025Article
- Pharmacotherapy for the core symptoms of autism spectrum disorder.Journal of Zhejiang University. Science. B · 2024Review
- Oxytocin pathway gene variation and corticostriatal resting-state functional connectivity.Comprehensive psychoneuroendocrinology · 2024Article
- DNA Methylation in Autism Spectrum Disorders: Biomarker or Pharmacological Target?Brain sciences · 2024Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 5 countries.
Funding
Abstract
Oxytocin may influence various human behaviors and the connectivity across subcortical and cortical networks. Previous oxytocin studies are male biased and often constrained by task-based inferences. Here, we investigate the impact of oxytocin on resting-state connectivity between subcortical and cortical networks in women. We collected resting-state functional magnetic resonance imaging (fMRI) data on 26 typically developing women 40 min following intranasal oxytocin administration using a double-blind placebo-controlled crossover design. Independent components analysis (ICA) was applied to examine connectivity between networks. An independent analysis of oxytocin receptor (OXTR) gene expression in human subcortical and cortical areas was carried out to determine plausibility of direct oxytocin effects on OXTR. In women, OXTR was highly expressed in striatal and other subcortical regions, but showed modest expression in cortical areas. Oxytocin increased connectivity between corticostriatal circuitry typically involved in reward, emotion, social communication, language and pain processing. This effect was 1.39 standard deviations above the null effect of no difference between oxytocin and placebo. This oxytocin-related effect on corticostriatal connectivity covaried with autistic traits, such that oxytocin-related increase in connectivity was stronger in individuals with higher autistic traits. In sum, oxytocin strengthened corticostriatal connectivity in women, particularly with cortical networks that are involved in social-communicative, motivational and affective processes. This effect may be important for future work on neurological and psychiatric conditions (for example, autism), particularly through highlighting how oxytocin may operate differently for subsets of individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.