Evidence map›Paper›PMID 28418004›Full record

ArticleScientific reports2017

Host Determinants of Expression of the Helicobacter pylori BabA Adhesin.

Mary E Kable, Lori M Hansen, Cathy M Styer, Samuel L Deck, Olena Rakhimova, Anna Shevtsova, Kathryn A Eaton, Miriam E Martin, Pär Gideonsson, Thomas Borén and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Pathogens (Basel, Switzerland) · 2024
    Review
  3. The immunopathogenesis ofFrontiers in microbiology · 2024
    Review
  4. Review
  5. Review
  6. Virulence of Helicobacter pylori outer membrane proteins: an updated review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Review
  7. Article
  8. Review
  9. Sexual dimorphism in bacterial infections.Biology of sex differences · 2018
    Review
  10. Genetic populations and virulence factors of Helicobacter pylori.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mary E KableUS Department of Agriculture, Western Human Nutrition Research Center, Davis, CA 95616, USA.
Lori M HansenCenter for Comparative Medicine, University of California, Davis, School of Medicine, Davis, CA 95616, USA.
Cathy M StyerCenter for Comparative Medicine, University of California, Davis, School of Medicine, Davis, CA 95616, USA.
Samuel L DeckCenter for Comparative Medicine, University of California, Davis, School of Medicine, Davis, CA 95616, USA.
Olena RakhimovaDepartment of Medical Biochemistry and Biophysics, Umeå University, Umeå SE-90187, Sweden.
Anna ShevtsovaDepartment of Medical Biochemistry and Biophysics, Umeå University, Umeå SE-90187, Sweden.
Kathryn A EatonDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Miriam E MartinCenter for Comparative Medicine, University of California, Davis, School of Medicine, Davis, CA 95616, USA.
Pär GideonssonDepartment of Medical Biochemistry and Biophysics, Umeå University, Umeå SE-90187, Sweden.
Thomas BorénDepartment of Medical Biochemistry and Biophysics, Umeå University, Umeå SE-90187, Sweden.
Jay V SolnickCenter for Comparative Medicine, University of California, Davis, School of Medicine, Davis, CA 95616, USA.

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
Modulation of Outer Membrane Protein Expressin in Helicobacter pyloriR01AI070803 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SOLNICK, JAY V. · 2008 to 2012
$2.4M
Role of H. pylori Outer Membrane Proteins in Colonization and Host ResponseR01AI081037 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SOLNICK, JAY V. · 2009 to 2013
$1.1M
NCI NIH HHS P30 CA093373NIAID NIH HHS R01 AI070803NIAID NIH HHS R01 AI081037NIH HHS P51 OD011107
6 · The paper itself

Abstract

Expression of the Helicobacter pylori blood group antigen binding adhesin A (BabA) is more common in strains isolated from patients with peptic ulcer disease or gastric cancer, rather than asymptomatic colonization. Here we used mouse models to examine host determinants that affect H. pylori BabA expression. BabA expression was lost by phase variation as frequently in WT mice as in RAG2-/- mice that do not have functional B or T cells, and in MyD88-/-, TLR2-/- and TLR4-/- mice that are defective in toll like receptor signaling. The presence of other bacteria had no effect on BabA expression as shown by infection of germ free mice. Moreover, loss of BabA expression was not dependent on Le

Indexed as

Gene Expression Regulation, BacterialHost-Pathogen InteractionsAdhesins, BacterialAnimalsDisease Models, AnimalFemaleHelicobacter InfectionsHelicobacter pyloriHumansMaleMiceMice, KnockoutAdhesins, BacterialBabA protein, Helicobacter pylori

Identifiers

PMID28418004
PMCPMC5394467

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.