Evidence map›Paper›PMID 28417994›Full record

ArticleThe American journal of gastroenterology2017

Trends in Epidemiology of Pediatric Inflammatory Bowel Disease in Canada: Distributed Network Analysis of Multiple Population-Based Provincial Health Administrative Databases.

Eric I Benchimol, Charles N Bernstein, Alain Bitton, Matthew W Carroll, Harminder Singh, Anthony R Otley, Maria Vutcovici, Wael El-Matary, Geoffrey C Nguyen, Anne M Griffiths and 12 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 155 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03262649 completednot on this map

Manitoba Inflammatory Bowel Disease Cohort Study

TypeobservationalSponsorUniversity of ManitobaRan2002 to 2016Enrolled388ConditionsInflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
NCT04624230 phase3active not recruitingnot on this mapstarted 2021, after this paper: background citation

Open-label induction and maintenance study of oral cp-690,550 (tofacitinib) in children with moderately to severely active ulcerative colitis

TypeinterventionalSponsorPfizerRan2021 to 2029Enrolled118ConditionsUlcerative ColitisArmstofacitinib
3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Eric I BenchimolDivision of Gastroenterology, Children's Hospital of Eastern Ontario IBD Centre, Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Eastern Ontario, Ottawa, Canada.
Charles N BernsteinUniversity of Manitoba IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Canada.
Alain BittonMcGill University Health Centre, Division of Gastroenterology, Montreal, Canada.
Matthew W CarrollDivision of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Harminder SinghUniversity of Manitoba IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Canada.
Anthony R OtleyDepartment of Pediatrics, Dalhousie University, Halifax, Canada.
Maria VutcoviciMcGill University Health Centre, Division of Gastroenterology, Montreal, Canada.
Wael El-MataryDepartment of Pediatrics, University of Manitoba, Winnipeg, Canada.
Geoffrey C NguyenInstitute for Clinical Evaluative Sciences, Toronto, Canada.
Anne M GriffithsDivision of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, Canada.
David R MackDivision of Gastroenterology, Children's Hospital of Eastern Ontario IBD Centre, Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Eastern Ontario, Ottawa, Canada.
Kevan JacobsonDepartment of Pediatrics, Child and Family Research Institute, University of British Columbia, British Columbia, Canada.
Nassim MojaverianInstitute for Clinical Evaluative Sciences, Toronto, Canada.
Divine TanyingohDepartments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
Yunsong CuiDepartment of Medicine, Dalhousie University, Halifax, Canada.
Zoann J NugentUniversity of Manitoba IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Canada.
Janie CoulombeMcGill University Health Centre, Division of Gastroenterology, Montreal, Canada.
Laura E TargownikUniversity of Manitoba IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Canada.
Jennifer L JonesDepartment of Medicine, Dalhousie University, Halifax, Canada.
Desmond LeddinDepartment of Medicine, Dalhousie University, Halifax, Canada.
Sanjay K MurthyInstitute for Clinical Evaluative Sciences, Toronto, Canada.
Gilaad G KaplanDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe incidence of pediatric-onset inflammatory bowel disease (IBD) is increasing worldwide. We used population-based health administrative data to determine national Canadian IBD incidence, prevalence, and trends over time of childhood-onset IBD.

methodsWe identified children <16 years (y) diagnosed with IBD 1999-2010 from health administrative data in five provinces (Alberta, Manitoba, Nova Scotia, Ontario, Quebec), comprising 79.2% of the Canadian population. Standardized incidence and prevalence were calculated per 100,000 children. Annual percentage change (APC) in incidence and prevalence were determined using Poisson regression analysis. Provincial estimates were meta-analyzed using random-effects models to produce national estimates.

results5,214 incident cases were diagnosed during the study period (3,462 Crohn's disease, 1,382 ulcerative colitis, 279 type unclassifiable). The incidence in Canada was 9.68 (95% CI 9.11 to 10.25) per 100,000 children. Incidence was similar amongst most provinces, but higher in Nova Scotia. APC in incidence did not significantly change over the study period in the overall cohort (+2.06%, 95% CI -0.64% to +4.76%). However, incidence significantly increased in children aged 0-5y (+7.19%, 95% +2.82% to +11.56%). Prevalence at the end of the study period in Canada was 38.25 (95% CI 35.78 to 40.73) per 100,000 children. Prevalence increased significantly over time, APC +4.56% (95% CI +3.71% to +5.42%).

conclusionsCanada has amongst the highest incidence of childhood-onset IBD in the world. Prevalence significantly increased over time. Incidence was not statistically changed with the exception of a rapid increase in incidence in the youngest group of children.

Indexed as

AdolescentCanadaChildChild, PreschoolDatabases, FactualFemaleHumansIncidenceInfantInflammatory Bowel DiseasesMalePrevalenceRetrospective Studies

Identifiers

PMID28417994
PMCPMC5527278

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.