Evidence map›Paper›PMID 28417982›Full record

ArticleProstate cancer and prostatic diseases2017

Total and beverage-specific alcohol intake and the risk of aggressive prostate cancer: a case-control study.

N P Papa, R J MacInnis, H Jayasekara, D R English, D Bolton, I D Davis, N Lawrentschuk, J L Millar, J Pedersen, G Severi and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Prostate cancer and prostatic diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Alcohol Intake and Risk of Lethal Prostate Cancer in the Health Professionals Follow-Up Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2019
    Article
  7. Dietary Carcinogens and DNA Adducts in Prostate Cancer.Advances in experimental medicine and biology · 2019
    Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

N P PapaCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.
R J MacInnisCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.
H JayasekaraCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.ORCID 0000-0002-2453-0183
D R EnglishCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.
D BoltonDepartment of Urology, Austin Health, Heidelberg, VIC, Australia.
I D DavisMonash University Eastern Health Clinical School, Box Hill, VIC, Australia.
N LawrentschukDepartment of Urology, Austin Health, Heidelberg, VIC, Australia.
J L MillarAlfred Health Radiation Oncology, The Alfred Hospital, Prahran, VIC, Australia.
J PedersenTissuPath, Melbourne, VIC, Australia.
G SeveriCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.
M C SoutheyGenetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, VIC, Australia.
J L HopperCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.
G G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.
The University of Melbourne · AUAustin Health · AUCancer Council Victoria · AUEastern Health · AUPeter MacCallum Cancer Centre · AUThe Alfred Hospital · AUTissuPath · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEthanol in alcoholic beverages is a known carcinogen, but its association with aggressive prostate cancer (APC) is uncertain. Recent studies have shown a modest increase in risk of APC associated with heavy alcohol intake while association for beverage types remain inconsistent.

methodsUsing a case-control design and self-administered questionnaire, we examined the association between APC (high grade and/or advanced stage) and frequency and quantity of alcohol intake 2 years prior to enrolment. Furthermore, we delineated the relationships for beverage-specific intakes of beer, red wine, white wine and spirits.

resultsThe study included 1282 APC cases and 951 controls. Beer intake frequency of ⩾5 days per week was associated with increased risk compared with no beer intake (odds ratio=1.66, 95% confidence interval: 1.12-2.48) whereas wine was protective at all frequencies of consumption compared with those with no wine intake. For every 10 g per week ethanol intake from beer increase, the odds of advanced PC rose by 3% (OR=1.03, 95% CI: 1.02-1.05). No such increased risk was observed for red or white wine while a marginal dose-response relationship was found for spirits (OR=1.03, 95% CI: 0.99-1.07).

conclusionsHeavy beer and possibly spirits consumption is associated with increased risk while no dose-response relationship was found for red or white wine. Wine drinkers at all frequencies have a decreased risk of APC compared with those who did not drink wine.

Indexed as

AgedAlcohol DrinkingCase-Control StudiesHumansMaleMiddle AgedNeoplasm GradingProstatic NeoplasmsRisk Factors

Identifiers

PMID28417982
OpenAlexW2605539790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.