ArticleInternational journal of molecular sciences2017
Histogram Analysis of Diffusion Weighted Imaging at 3T is Useful for Prediction of Lymphatic Metastatic Spread, Proliferative Activity, and Cellularity in Thyroid Cancer.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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48 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Meta-analysis of prediction models for predicting lymph node metastasis in thyroid cancer.World journal of surgical oncology · 2024Pooled it
- MRI characteristics of cervical radioiodine-avid lymph nodes detected on post-therapeutic ¹³¹I whole-body scintigraphy in differentiated thyroid carcinoma.Frontiers in endocrinology · 2026Article
- Association between histogram parameters of T2 weighted MRI data, WHO grade, tumor proliferation index and selected molecular markers in low-grade glioma.Frontiers in radiology · 2026Article
- Sinonasal adenoid cystic carcinoma: preoperative apparent diffusion coefficient histogram analysis in prediction of prognosis and Ki-67 proliferation status.Japanese journal of radiology · 2025Article
- Differential diagnosis of atypical and anaplastic meningiomas based on conventional MRI features and ADC histogram parameters using a logistic regression model nomogram.Neurosurgical review · 2023Article
- Incremental prognostic value of ADC histogram analysis in patients with high-risk prostate cancer receiving adjuvant hormonal therapy after radical prostatectomy.Frontiers in oncology · 2023Article
- Prognostic value of apparent diffusion coefficient in neuroendocrine carcinomas of the uterine cervix.PeerJ · 2023Article
- The role of apparent diffusion coefficient histogram metrics for differentiating pediatric medulloblastoma histological variants and molecular groups.Pediatric radiology · 2022Article
- Histogram-based analysis of diffusion-weighted imaging for predicting aggressiveness in papillary thyroid carcinoma.BMC medical imaging · 2022Article
- Quantitative differentiation of malignant and benign thyroid nodules with multi-parameter diffusion-weighted imaging.World journal of clinical cases · 2022Article
- Diffusion Weighted Imaging in Gliomas: A Histogram-Based Approach for Tumor Characterization.Cancers · 2022Article
- Which Parameter Influences Local Disease-Free Survival after Radiation Therapy Due to Osteolytic Metastasis? A Retrospective Study with Pre- and Post-Radiation Therapy MRI including Diffusion-Weighted Images.Journal of clinical medicine · 2021Article
- Novel MRI-Based CAD System for Early Detection of Thyroid Cancer Using Multi-Input CNN.Sensors (Basel, Switzerland) · 2021Article
- Article
- Histogram Analysis of Diffusion-Weighted MR Imaging as a Biomarker to Predict Survival of Surgically Treated Colorectal Cancer Patients.Digestive diseases and sciences · 2021Article
- Value of Apparent Diffusion Coefficient Histogram Analysis in the Differential Diagnosis of Nasopharyngeal Lymphoma and Nasopharyngeal Carcinoma Based on Readout-Segmented Diffusion-Weighted Imaging.Frontiers in oncology · 2021Article
- Diffusion weighted imaging in high-grade gliomas: A histogram-based analysis of apparent diffusion coefficient profile.PloS one · 2021Article
- Article
- MRI-based radiomics analysis to predict preoperative lymph node metastasis in papillary thyroid carcinoma.Gland surgery · 2020Article
- Performance of diffusion and perfusion MRI in evaluating primary central nervous system lymphomas of different locations.BMC medical imaging · 2020Article
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10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pre-surgical diffusion weighted imaging (DWI) is increasingly important in the context of thyroid cancer for identification of the optimal treatment strategy. It has exemplarily been shown that DWI at 3T can distinguish undifferentiated from well-differentiated thyroid carcinoma, which has decisive implications for the magnitude of surgery. This study used DWI histogram analysis of whole tumor apparent diffusion coefficient (ADC) maps. The primary aim was to discriminate thyroid carcinomas which had already gained the capacity to metastasize lymphatically from those not yet being able to spread via the lymphatic system. The secondary aim was to reflect prognostically important tumor-biological features like cellularity and proliferative activity with ADC histogram analysis. Fifteen patients with follicular-cell derived thyroid cancer were enrolled. Lymph node status, extent of infiltration of surrounding tissue, and Ki-67 and p53 expression were assessed in these patients. DWI was obtained in a 3T system using
conclusionshistogram analysis of whole ADC tumor volumes has the potential to provide valuable information on tumor biology in thyroid carcinoma. However, further studies are warranted.
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