ArticleMicrobial biotechnology2017
Caboxamycin biosynthesis pathway and identification of novel benzoxazoles produced by cross-talk in Streptomyces sp. NTK 937.
Article in Microbial biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Dual Silencing of Aminoglycoside Biosynthesis for the Discovery of Novel Antimicrobials in Streptomyces.Microbial biotechnology · 2026Article
- Integrated genome mining and molecular networking uncover the biosynthetic potential of a novel mangrove-derived strain Streptomyces sp. B1866.BMC genomics · 2025Article
- Discovery and In Vitro Reconstitution of Closoxazole Biosynthesis from Pyxidicoccus fallax.Chembiochem : a European journal of chemical biology · 2025Article
- Critical analysis of polycyclic tetramate macrolactam biosynthetic gene cluster phylogeny and functional diversity.Applied and environmental microbiology · 2024Article
- Caboxamycin Inhibits Heart Inflammation in a Coxsackievirus B3-Induced Myocarditis Mouse Model.Viruses · 2024Article
- Non-canonical two-step biosynthesis of anti-oomycete indole alkaloids in Kickxellales.Fungal biology and biotechnology · 2023Article
- Genomics-Driven Discovery of Benzoxazole Alkaloids from the Marine-DerivedMolecules (Basel, Switzerland) · 2023Article
- Alternative Benzoxazole Assembly Discovered in Anaerobic Bacteria Provides Access to Privileged Heterocyclic Scaffold.Angewandte Chemie (International ed. in English) · 2022Article
- Promising bioactive compounds from the marine environment and their potential effects on various diseases.Journal, genetic engineering & biotechnology · 2022Review
- An in-cluster Sfp-type phosphopantetheinyl transferase instead of theFrontiers in chemistry · 2022Article
- Natural products, including a new caboxamycin, fromFrontiers in chemistry · 2022Article
- An Overview of Bioactive 1,3-Oxazole-Containing Alkaloids from Marine Organisms.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Influence of Amino Acid Feeding on Production of Calcimycin and Analogs inInternational journal of environmental research and public health · 2021Article
- Construction of an Alternative NADAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Isolation and Evaluation of Rhizosphere Actinomycetes With Potential Application for BiocontrollingFrontiers in microbiology · 2021Article
- The Biosynthesis of the Benzoxazole in Nataxazole Proceeds via an Unstable Ester and has Synthetic Utility.Angewandte Chemie (International ed. in English) · 2020Article
- Antarctic Streptomyces fildesensis So13.3 strain as a promising source for antimicrobials discovery.Scientific reports · 2019Article
- Discovery of 16-Demethylrifamycins by Removing the Predominant Polyketide Biosynthesis Pathway inApplied and environmental microbiology · 2019Article
- Antifungal, Plant Growth-Promoting, and Genomic Properties of an Endophytic ActinobacteriumFrontiers in microbiology · 2019Article
- Comparative Genomics of Marine Sponge-DerivedFrontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptomyces sp. NTK937, producer of benzoxazole antibiotic caboxamycin, produces in addition a methyl ester derivative, O-methylcaboxamycin. Caboxamycin cluster, comprising one regulatory and nine structural genes, has been delimited, and each gene has been individually inactivated to demonstrate its role in the biosynthetic process. The O-methyltransferase potentially responsible for O-methylcaboxamycin synthesis would reside outside this cluster. Five of the genes, cbxR, cbxA, cbxB, cbxD and cbxE, encoding a SARP transcriptional regulator, salicylate synthase, 3-oxoacyl-ACP-synthase, ACP and amidohydrolase, respectively, have been found to be essential for caboxamycin biosynthesis. The remaining five structural genes were found to have paralogues distributed throughout the genome, capable of partaking in the process when their cluster homologue is inactivated. Two of such paralogues, cbxC' and cbxI', coding an AMP-dependent synthetase-ligase and an anthranilate synthase, respectively, have been identified. However, the other three genes might simultaneously have more than one paralogue, given that cbxF (DAHP synthase), cbxG (2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase) and cbxH (isochorismatase) have three, three and five putative paralogue genes, respectively, of similar function within the genome. As a result of genetic manipulation, a novel benzoxazole (3'-hydroxycaboxamycin) has been identified in the salicylate synthase-deficient mutant strain ΔcbxA. 3'-hydroxycaboxamycin derives from the cross-talk between the caboxamycin and enterobactin pathways.
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