ArticleFEBS letters2017
The pathway intermediate 2-keto-3-deoxy-L-galactonate mediates the induction of genes involved in D-galacturonic acid utilization in Aspergillus niger.
Article in FEBS letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- The Zn(II)2Cys6 transcription factorApplied and environmental microbiology · 2026Article
- The genome-scale sugar metabolic model fromCurrent research in microbial sciences · 2026Article
- Metabolic engineering reveals the relative importance of different sugar catabolic pathways during consumption of plant biomass byCurrent research in microbial sciences · 2025Article
- Dissecting the complex regulation of pentose utilization inCurrent research in microbial sciences · 2025Article
- Catabolism of 2-keto-3-deoxy-galactonate and the production of its enantiomers.Applied microbiology and biotechnology · 2024Review
- Regulation of nutrient utilization in filamentous fungi.Applied microbiology and biotechnology · 2023Review
- The Sugar Metabolic Model ofJournal of fungi (Basel, Switzerland) · 2022Article
- The chimeric GaaR-XlnR transcription factor induces pectinolytic activities in the presence of D-xylose in Aspergillus niger.Applied microbiology and biotechnology · 2021Article
- Identification of a Conserved Transcriptional Activator-Repressor Module Controlling the Expression of Genes Involved in Tannic Acid Degradation and Gallic Acid Utilization inFrontiers in fungal biology · 2021Article
- Re-routing of Sugar Catabolism Provides a Better Insight Into Fungal Flexibility in Using Plant Biomass-Derived Monomers as Substrates.Frontiers in bioengineering and biotechnology · 2021Article
- Comparative Characterization ofFrontiers in bioengineering and biotechnology · 2020Article
- W361R mutation in GaaR, the regulator of D-galacturonic acid-responsive genes, leads to constitutive production of pectinases in Aspergillus niger.MicrobiologyOpen · 2019Article
- Microbial hexuronate catabolism in biotechnology.AMB Express · 2019Review
- The gold-standard genome ofStudies in mycology · 2018Article
- Inducer-independent production of pectinases in Aspergillus niger by overexpression of the D-galacturonic acid-responsive transcription factor gaaR.Applied microbiology and biotechnology · 2018Article
- Modulating Transcriptional Regulation of Plant Biomass Degrading Enzyme Networks for Rational Design of Industrial Fungal Strains.Frontiers in bioengineering and biotechnology · 2018Review
- A community-driven reconstruction of theFungal biology and biotechnology · 2018Article
- Expression-based clustering of CAZyme-encoding genes of Aspergillus niger.BMC genomics · 2017Article
- In vivo functional analysis of L-rhamnose metabolic pathway in Aspergillus niger: a tool to identify the potential inducer of RhaR.BMC microbiology · 2017Article
- Combinatorial control of gene expression in Aspergillus niger grown on sugar beet pectin.Scientific reports · 2017Article
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Aspergillus niger, the enzymes encoded by gaaA, gaaB, and gaaC catabolize d-galacturonic acid (GA) consecutively into l-galactonate, 2-keto-3-deoxy-l-galactonate, pyruvate, and l-glyceraldehyde, while GaaD converts l-glyceraldehyde to glycerol. Deletion of gaaB or gaaC results in severely impaired growth on GA and accumulation of l-galactonate and 2-keto-3-deoxy-l-galactonate, respectively. Expression levels of GA-responsive genes are specifically elevated in the ∆gaaC mutant on GA as compared to the reference strain and other GA catabolic pathway deletion mutants. This indicates that 2-keto-3-deoxy-l-galactonate is the inducer of genes required for GA utilization.
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