ReviewCurrent environmental health reports2017
Developmental Neurotoxicity of Traffic-Related Air Pollution: Focus on Autism.
Review in Current environmental health reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Particulate Matter Exposure and Attention-Deficit/Hyperactivity Disorder in Children: A Systematic Review of Epidemiological Studies.International journal of environmental research and public health · 2019Pooled it
- The Interplay of Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation in Autism Spectrum Disorder: Behavioral Implications and Therapeutic Strategies.Brain sciences · 2025Review
- Sensitive periods for exposure to indoor air pollutants and psychosocial factors in association with symptoms of psychopathology at school-age in a South African birth cohort.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Associations between Ultrafine Particles and Incident Dementia in Older Adults.Environmental science & technology · 2025Article
- Chemogenetic induction of CA1 hyperexcitability triggers indistinguishable autistic traits in asymptomatic mice differing in Ambra1 expression and sex.Translational psychiatry · 2025Article
- Article
- Foreign Contaminants Target Brain Health.CNS & neurological disorders drug targets · 2025Review
- Fetal development and the air pollution exposome: an integrative perspective of health pathways.Frontiers in cellular neuroscience · 2025Article
- Protecting Public Health With Clean Transportation in North Carolina.Environmental health insights · 2025Article
- Urban residential greenness and cancer mortality: Evaluating the causal mediation role of air pollution in a large cohort.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Joint effects of indoor air pollution and maternal psychosocial factors during pregnancy on trajectories of early childhood psychopathology.American journal of epidemiology · 2024Article
- The Autism Spectrum Disorder and Its Possible Origins in Pregnancy.International journal of environmental research and public health · 2024Review
- Article
- Exposure to local, source-specific ambient air pollution during pregnancy and autism in children: a cohort study from southern Sweden.Scientific reports · 2023Article
- Article
- Air Pollution: Possible Interaction between the Immune and Nervous System?International journal of environmental research and public health · 2022Review
- Fetal Exposure to Air Pollution in Late Pregnancy Significantly Increases ADHD-Risk Behavior in Early Childhood.International journal of environmental research and public health · 2022Article
- Unequal effects of climate change and pre-existing inequalities on the mental health of global populations.BJPsych bulletin · 2021Article
- Metabolomics analysis of maternal serum exposed to high air pollution during pregnancy and risk of autism spectrum disorder in offspring.Environmental research · 2021Article
- Association of the global distribution of multiple sclerosis with ultraviolet radiation and air pollution: an ecological study based on GBD data.Environmental science and pollution research international · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewEpidemiological and animal studies suggest that air pollution may negatively affect the central nervous system (CNS) and contribute to CNS diseases. Traffic-related air pollution is a major contributor to global air pollution, and diesel exhaust (DE) is its most important component. RECENT
findingsSeveral studies suggest that young individuals may be particularly susceptible to air pollution-induced neurotoxicity and that perinatal exposure may cause or contribute to developmental disabilities and behavioral abnormalities. In particular, a number of recent studies have found associations between exposures to traffic-related air pollution and autism spectrum disorders (ASD), which are characterized by impairment in socialization and in communication and by the presence of repetitive and unusual behaviors. The cause(s) of ASD are unknown, and while it may have a hereditary component, environmental factors are increasingly suspected as playing a pivotal role in its etiology, particularly in genetically susceptible individuals. Autistic children present higher levels of neuroinflammation and systemic inflammation, which are also hallmarks of exposure to traffic-related air pollution. Gene-environment interactions may play a relevant role in determining individual susceptibility to air pollution developmental neurotoxicity. Given the worldwide presence of elevated air pollution, studies on its effects and mechanisms on the developing brain, genetic susceptibility, role in neurodevelopmental disorders, and possible therapeutic interventions are certainly warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.