ArticleEndocrine2017
Impact of season and different vitamin D thresholds on prevalence of vitamin D deficiency in epidemiological cohorts-a note of caution.
Article in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Pooled it
- Effect of an vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients - a randomized controlled trial: study protocol.BMC psychiatry · 2018Trial
- Association between Serum Adiponectin and Vitamin D in Obese Pre- and Early Postmenopausal Women: A Cross-Sectional Study.Journal of menopausal medicine · 2026Article
- The impact of season, temperature, and direct normal irradiance on IVF pregnancy outcomes: a retrospective cohort study.International journal of biometeorology · 2025Article
- Improved bioavailability of buccal nanoemulsion vitamin D compared to conventional oral supplementation in patients with inflammatory bowel disease: a randomized controlled trial.Frontiers in medicine · 2025Article
- Longitudinal analysis of vitamin D levels considering sunshine duration and suggestion for a standardised approach for vitamin D supplementation in children and adolescents with obesity.BMC pediatrics · 2024Article
- The comparisons of vitamin D3 levels in IgA vasculitis across different subgroups and healthy children: a comparative study.Translational pediatrics · 2023Article
- Association between Malnutrition and Dental Caries in Iraqi Kurdish Children.Dentistry journal · 2023Article
- 25-hydroxyvitamin D level is associated with greater grip strength across adult life span: a population-based cohort study.Endocrine connections · 2023Article
- Association of vitamin D levels and polymorphisms in vitamin D receptor with type 2 diabetes mellitus.Biomedical reports · 2023Article
- Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group.Aging clinical and experimental research · 2022Review
- Association between anthropometric markers of adiposity, adipokines and vitamin D levels.Scientific reports · 2022Article
- Histopathological role of vitamin D deficiency in recurrent/chronic tonsillitis pathogenesis: Vascular epithelial growth factor-mediated angiogenesis in tonsil.Clinical and experimental dental research · 2022Article
- Association between serum vitamin D status and the anti-seizure treatment in Chinese children with epilepsy.Frontiers in nutrition · 2022Article
- A critical update on the role of mild and serious vitamin D deficiency prevalence and the COVID-19 epidemic in Europe.Nutrition (Burbank, Los Angeles County, Calif.) · 2022Article
- Additive effects of obesity and vitamin D insufficiency on all-cause and cause-specific mortality.Frontiers in nutrition · 2022Article
- The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?International journal of general medicine · 2021Review
- Screen Time, Age and Sunshine Duration Rather Than Outdoor Activity Time Are Related to Nutritional Vitamin D Status in Children With ASD.Frontiers in pediatrics · 2021Article
- Bone Metabolism and Vitamin D Implication in Gastroenteropancreatic Neuroendocrine Tumors.Nutrients · 2020Review
- Lower serum 25-hydroxyvitamin D levels are associated with impaired glomerular filtration rate in type 2 diabetes patients.Therapeutic advances in endocrinology and metabolism · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe investigated the impact of different cut-offs on the prevalence of 25-hydroxyvitamin D [25-(OH)D] deficiency.
methodsWe used baseline data of 4149 participants (45-75 years, 50% women) of the population-based Heinz Nixdorf Recall study. Serum 25-(OH)D was measured with the Roche Cobas assay. Quartiles (p25, p50, and p75) were calculated. Data were stratified by months, sex, and age. According to the recommendations of 'Dachverband Osteologie', Endocrine Society and National Institute of Health we used 25-(OH)D thresholds of 12, 20, and 30 ng/ml to estimate vitamin D deficiency.
resultsOverall the median of 25-(OH)D was 19.8 ng/ml (p25 = 14.4 ng/ml, p75 = 26.6 ng/ml), with highest concentrations in July (p50 = 23.8 ng/ml, p25 = 18.2 ng/ml, and p75 = 31.2 ng/ml) and lowest in March (p50 = 15.8 ng/ml, p25 = 11.5 ng/ml, and p75 = 20.6 ng/ml). Prevalence of vitamin D deficiency rose from 16, 51 up to 83% using the cut-offs of <12, <20 ng/ml, and <30 ng/ml, respectively. With respect to seasonal variance, prevalence of vitamin D deficiency rose to 92% in February/March using the cut-off <30 ng/ml (<12: 28%, <20 ng/ml: 71%) whereas in June/July prevalence of vitamin D deficiency decreased to 71% (<12: 6%, <20 ng/ml: 30%). The chance to attest the diagnosis of vitamin D deficiency for cut-off 12 ng/ml in March is 6.4-fold higher than in June, for cut-off 20 ng/ml, 5.5-fold higher and for cut-off 30 ng/ml, 3.1-fold higher.
conclusionsGuidelines to define vitamin D deficiency revealed extremely different prevalence rates ranging between 6 and 92%. Accounting for collection time and antecedent sun exposure are important to reduce bias in research studies and improve decision-making in clinical care. Vitamin D thresholds have to be rethought.
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