ArticleJournal of the American Society for Mass Spectrometry2017
Uncovering Structural Diversity of Unsaturated Fatty Acyls in Cholesteryl Esters via Photochemical Reaction and Tandem Mass Spectrometry.
Article in Journal of the American Society for Mass Spectrometry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Recent advances in the analysis of unsaturated fatty acids in biological samples based on chemical derivatization and mass spectrometry techniques.Journal of pharmaceutical analysis · 2026Review
- Quantitative Analysis and Structural Elucidation of Fatty Acids by Isobaric Multiplex Labeling Reagents for Carbonyl-Containing Compound (SUGAR) Tags andAnalytical chemistry · 2022Article
- Methods of Lipidomic Analysis: Extraction, Derivatization, Separation, and Identification of Lipids.Advances in experimental medicine and biology · 2021Article
- Comprehensive Structural Characterization of Lipids by Coupling Paternò-Büchi Reaction and Tandem Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Double bond localization in unsaturated rhamnolipid precursors 3-(3-hydroxyalkanoyloxy)alkanoic acids by liquid chromatography-mass spectrometry applying online Paternò-Büchi reaction.Analytical and bioanalytical chemistry · 2020Article
- Lipidome-wide characterization of phosphatidylinositols and phosphatidylglycerols on CC location level.Analytica chimica acta · 2020Article
- Coupling Headgroup and Alkene Specific Solution Modifications with Gas-Phase Ion/Ion Reactions for Sensitive Glycerophospholipid Identification and Characterization.Journal of the American Society for Mass Spectrometry · 2020Article
- Lipid Alterations during Zebrafish Embryogenesis Revealed by Dynamic Mass Spectrometry Profiling with C=C Specificity.Journal of the American Society for Mass Spectrometry · 2019Article
- Mapping Lipid C=C Location Isomers in Organ Tissues by Coupling Photochemical Derivatization and Rapid Extractive Mass Spectrometry.International journal of mass spectrometry · 2019Article
- Mapping Unsaturation in Human Plasma Lipids by Data-Independent Ozone-Induced Dissociation.Journal of the American Society for Mass Spectrometry · 2019Article
- New Frontiers in Lipidomics Analyses using Structurally Selective Ion Mobility-Mass Spectrometry.Trends in analytical chemistry : TRAC · 2019Article
- In-depth structural characterization of phospholipids by pairing solution photochemical reaction with charge inversion ion/ion chemistry.Analytical and bioanalytical chemistry · 2019Article
- Reshaping Lipid Biochemistry by Pushing Barriers in Structural Lipidomics.Angewandte Chemie (International ed. in English) · 2019Review
- Identification of Double Bond Position Isomers in Unsaturated Lipids by m-CPBA Epoxidation and Mass Spectrometry Fragmentation.Analytical chemistry · 2019Article
- Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers.Nature communications · 2019Article
- Coupling the Paternò-Büchi (PB) Reaction With Mass Spectrometry to Study Unsaturated Fatty Acids in Mouse Model of Multiple Sclerosis.Frontiers in chemistry · 2019Article
- Systematic Analysis of Fatty Acids in Human Cells with a Multiplexed Isobaric Tag (TMT)-Based Method.Journal of proteome research · 2018Article
- Recent advances in lipid separations and structural elucidation using mass spectrometry combined with ion mobility spectrometry, ion-molecule reactions and fragmentation approaches.Current opinion in chemical biology · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Mass spectrometry analysis of cholesteryl esters (CEs) faces several challenges, with one of them being the determination of the carbon-carbon double bond (C=C) locations within unsaturated fatty acyl chains. Paternὸ-Büchi (PB) reaction, a photochemical reaction based on the addition of acetone to C=C, is capable of C=C location determination when coupled with tandem mass spectrometry (MS/MS). In this study, the PB reaction conditions were tailored for CEs and subsequent nanoelectrospray ionization (nanoESI). A solvent system containing acetone/methanol/dichloromethane/water (40/30/20/10, volume ratios) and 100 μM LiOH was determined to be optimal, resulting in reasonable PB reaction yield (~30%) and good ionization efficiency (forming lithium adduct of CEs). Collision-induced dissociation (CID) of the PB reaction products produced characteristic fragment ions of CE together with those modified by the PB reactions, such as lithiated fatty acyl ([FA + Li]
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