ArticleBrain structure & function2017
A posterior-to-anterior shift of brain functional dynamics in aging.
Article in Brain structure & function, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Tai Chi modulating multimodal connectivity patterns and cognitive function in cerebral small vessel disease.GeroScience · 2026Trial
- Brain Perfusion Change in Patients with Mild Cognitive Impairment After 12 Months of Aerobic Exercise Training.Journal of Alzheimer's disease : JAD · 2020Trial
- Age-Related Changes in Spontaneous Brain Dynamics Revealed by Resting-State Magnetoencephalography.GeroScience · 2026Article
- Increased frontal functional connectivity correlates with structural disconnection in the anterior corpus callosum in healthy older adults.Scientific reports · 2025Article
- Linking Individual Variability of Multi-modal Connectivity, Lifestyle, Psycho-Social Factors and Cognition in Older Adults.Aging and disease · 2025Article
- Age Differences in Brain Functional Connectivity Underlying Proactive Interference in Working Memory.Human brain mapping · 2025Article
- Brain network dynamics in patients with single- and multiple-domain amnestic mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Toward a more comprehensive understanding of network centrality disruption in amnestic mild cognitive impairment: a MEG multilayer approach.Alzheimer's research & therapy · 2024Article
- Neuroimaging and plasma evidence of early white matter loss in Parkinson's disease with poor outcomes.Brain communications · 2024Article
- Influence of atlas-choice on age and time effects in large-scale brain networks in the context of healthy aging.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Examining the influence of self-care practices on brain activity in healthy older adults.Frontiers in aging neuroscience · 2024Article
- Article
- Individual functional parcellation revealed compensation of dynamic limbic network organization in healthy ageing.Human brain mapping · 2023Article
- The Overview of Cognitive Aging Models.Advances in experimental medicine and biology · 2023Article
- Chinese adult brain atlas with functional and white matter parcellation.Scientific data · 2022Article
- Functional Connectivity Dynamics Altered of the Resting Brain in Subjective Cognitive Decline.Frontiers in aging neuroscience · 2022Article
- BDNF and KIBRA Polymorphisms Are Related to Altered Resting State Network Connectivity in Middle Age.Journal of Alzheimer's disease : JAD · 2022Article
- Trends in regional morphological changes in the brain after the resolution of hypercortisolism in Cushing's disease: a complex phenomenon, not mere partial reversibility.Endocrine connections · 2021Article
- Atlas55+: Brain Functional Atlas of Resting-State Networks for Late Adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
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3 authors.
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Abstract
Convergent evidence from task-based functional magnetic resonance imaging (fMRI) studies suggests a posterior-to-anterior shift as an adaptive compensatory scaffolding mechanism for aging. This study aimed to investigate whether brain functional dynamics at rest follow the same scaffolding mechanism for aging using a large Chinese sample aged from 22 to 79 years (n = 277). We defined a probability of brain regions being hubs over a period of time to characterize functional hub dynamic, and defined variability of the functional connectivity to characterize dynamic functional connectivity using resting-state fMRI. Our results revealed that both functional hub dynamics and dynamic functional connectivity posited an age-related posterior-to-anterior shift. Specifically, the posterior brain region showed attenuated dynamics, while the anterior brain regions showed augmented dynamics in aging. Interestingly, our analysis further indicated that the age-related episodic memory decline was associated with the age-related decrease in the brain functional dynamics of the posterior regions. Hence, these findings provided a new dimension to view the scaffolding mechanism for aging based on the brain functional dynamics.
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