ArticleBrain structure & function2017
Healthy cortical development through adolescence and early adulthood.
Article in Brain structure & function, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cortical Gyrification Morphology in Individuals with ASD and ADHD across the Lifespan: A Systematic Review and Meta-Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2021Pooled it
- Perspectives on Human Cingulate Cortex Functional Organization From Cortical Electrical Stimulation Mapping.CNS neuroscience & therapeutics · 2026Article
- Morphometric alterations of the gray matter of the frontal lobe during childhood in healthy children born prematurely. Repercussions of foetal and postnatal growth restriction.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- From Developmental Timing to Clinical Visibility: An Integrative Narrative Review of Sex-Related Neurocognitive Development.Children (Basel, Switzerland) · 2026Review
- Neuro-ophthalmic findings of Visual Snow Syndrome in Korea.Japanese journal of ophthalmology · 2025Article
- [Long-term courses of bipolar disorders].Der Nervenarzt · 2025Review
- What is the neurobiology of schizophrenia?CNS spectrums · 2024Review
- Association of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018.JAMA network open · 2023Article
- Genetic risks of Alzheimer's byBrain communications · 2023Article
- Cortical Gyrification Morphology in ASD and ADHD: Implication for Further Similarities or Disorder-Specific Features?Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Cortical Gyrification Morphology in Adult Males with Mild Traumatic Brain Injury.Neurotrauma reports · 2022Article
- Cortical Gyrification in Transgender Individuals.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Cortical gyrification morphology in PTSD: A neurobiological risk factor for severity?Neurobiology of stress · 2021Article
- Brief Postnatal Visual Deprivation Triggers Long-Lasting Interactive Structural and Functional Reorganization of the Human Cortex.Frontiers in medicine · 2021Article
- Cortical gyrification and its relationships with molecular measures and cognition in children with the FMR1 premutation.Scientific reports · 2020Article
- Mapping the neuroanatomical impact of very preterm birth across childhood.Human brain mapping · 2020Article
- Cortical morphometry in anorexia nervosa: An out-of-sample replication study.European eating disorders review : the journal of the Eating Disorders Association · 2019Article
- A Longitudinal Study of Local Gyrification Index in Young Boys With Autism Spectrum Disorder.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- The Protracted Maturation of Associative Layer IIIC Pyramidal Neurons in the Human Prefrontal Cortex During Childhood: A Major Role in Cognitive Development and Selective Alteration in Autism.Frontiers in psychiatry · 2019Article
- Developmental Trajectories of the Orbitofrontal Cortex and Anhedonia in Middle Childhood and Risk for Substance Use in Adolescence in a Longitudinal Sample of Depressed and Healthy Preschoolers.The American journal of psychiatry · 2018Article
Corrections and comments
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Adolescence is a period of significant brain changes; however, the effects of age and sex on cortical development are yet to be fully characterized. Here, we utilized innovative intrinsic curvature (IC) analysis, along with the traditional cortical measures [cortical thickness (CT), local gyrification index (LGI), and surface area (SA)], to investigate how these indices (1) relate to each other and (2) depend on age and sex in adolescent cortical development. T1-weighted magnetic resonance images from 218 healthy volunteers (age range 8.3-29.2 years, M[SD] = 16.5[3.4]) were collected at two sites and processed with FreeSurfer and Caret software packages. Surface indices were extracted per cortex area (frontal, parietal, occipital, temporal, insula, and cingulate). Correlation analyses between the surface indices were conducted and age curves were modelled using generalized additive mixed-effect models. IC showed region-specific associations with LGI, SA, and CT, as did CT with LGI. SA was positively associated with LGI in all regions and CT in none. CT and LGI, but not SA, were inversely associated with age in all regions. IC was inversely associated with age in all but the occipital region. For all regions, males had larger cortical SA than females. Males also had larger LGI in all regions and larger IC of the frontal area; however, these effects were accounted for by sex differences in SA. There were no age-by-sex interactions. The study of IC adds a semi-independent, sensitive measure of cortical morphology that relates to the underlying cytoarchitecture and may aid understanding of normal brain development and deviations from it.
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