Evidence map›Paper›PMID 28417112›Full record

ArticleScience immunology2016

Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients.

Thomas Condamine, George A Dominguez, Je-In Youn, Andrew V Kossenkov, Sridevi Mony, Kevin Alicea-Torres, Evgenii Tcyganov, Ayumi Hashimoto, Yulia Nefedova, Cindy Lin and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 530 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
530citing papers in PubMed, 2 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

530 citing papers in PubMed, 2 syntheses or guidelines pooled it, 782 citations in OpenAlex.

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470 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 4 institutions in 2 countries.

Thomas CondamineThe Wistar Institute, Philadelphia, PA, 19104, USA.
George A DominguezThe Wistar Institute, Philadelphia, PA, 19104, USA.
Je-In YounThe Wistar Institute, Philadelphia, PA, 19104, USA.
Andrew V KossenkovThe Wistar Institute, Philadelphia, PA, 19104, USA.
Sridevi MonyThe Wistar Institute, Philadelphia, PA, 19104, USA.
Kevin Alicea-TorresThe Wistar Institute, Philadelphia, PA, 19104, USA.
Evgenii TcyganovThe Wistar Institute, Philadelphia, PA, 19104, USA.
Ayumi HashimotoThe Wistar Institute, Philadelphia, PA, 19104, USA.
Yulia NefedovaThe Wistar Institute, Philadelphia, PA, 19104, USA.
Cindy LinThe Wistar Institute, Philadelphia, PA, 19104, USA.
Simona PartlovaThe Wistar Institute, Philadelphia, PA, 19104, USA.
Alfred GarfallAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Dan T VoglAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Xiaowei XuAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Stella C KnightAntigen Presentation Research Group, Imperial College London, London, UK HA1 3UJ.
George MalietzisAntigen Presentation Research Group, Imperial College London, London, UK HA1 3UJ.
Gui Han LeeAntigen Presentation Research Group, Imperial College London, London, UK HA1 3UJ.
Evgeniy EruslanovAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Steven M AlbeldaAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Xianwei WangDepartment of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Jawahar L MehtaDepartment of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Meenakshi BewtraDivision of Gastroenterology, Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Anil RustgiAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Neil HocksteinHelen F. Graham Cancer Center & Research Institute, Christiana Care Health System, Newark, DE 19713, USA.
Robert WittHelen F. Graham Cancer Center & Research Institute, Christiana Care Health System, Newark, DE 19713, USA.
Gregory MastersHelen F. Graham Cancer Center & Research Institute, Christiana Care Health System, Newark, DE 19713, USA.
Brian NamHelen F. Graham Cancer Center & Research Institute, Christiana Care Health System, Newark, DE 19713, USA.
Denis SmirnovJanssen Oncology Therapeutic Area, Janssen Research and Development, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, PA, 19477, USA.
Manuel A SepulvedaJanssen Oncology Therapeutic Area, Janssen Research and Development, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, PA, 19477, USA.
Dmitry I GabrilovichThe Wistar Institute, Philadelphia, PA, 19104, USA.
The Wistar Institute · USUniversity of Pennsylvania · USSt Mark's Hospital · GBUniversity of Arkansas for Medical Sciences · US

Funding

Transformed Esophageal Epithelial Cells and the Tumor MicroenvironmentP01CA098101 · NCI · UNIVERSITY OF PENNSYLVANIA · PI RUSTGI, ANIL K · 2003 to 2023
$31.7M
TRAINING PROGRAM IN BASIC CANCER RESEARCHT32CA009171 · NCI · WISTAR INSTITUTE · PI Alessandro Gardini · 1985 to 2026
$15.3M
Correction of myeloid cell defects in cancerR01CA084488 · NCI · WISTAR INSTITUTE · PI GABRILOVICH, DMITRY I · 1999 to 2017
$5.4M
Mechanism of myeloid cell defect in cancerR01CA100062 · NCI · WISTAR INSTITUTE · PI GABRILOVICH, DMITRY I · 2004 to 2018
$4.0M
Lipids and Myeloid Cell Function in CancerR01CA165065 · NCI · WISTAR INSTITUTE · PI KAGAN, VALERIAN E, MONTANER, LUIS J · 2012 to 2022
$3.8M
Tumor-associated neutrophils in human lung cancerR01CA187392 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ERUSLANOV, EVGENIY · 2016 to 2020
$1.8M
Integrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center LevelR50CA211199 · NCI · WISTAR INSTITUTE · PI Andrew V Kossenkov · 2016 to 2026
$1.6M
NCI NIH HHS P01 CA098101NCI NIH HHS R01 CA084488NCI NIH HHS R01 CA100062NCI NIH HHS R01 CA165065NCI NIH HHS R01 CA187392NCI NIH HHS R50 CA211199NCI NIH HHS T32 CA009171
6 · The paper itself

Abstract

Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) are important regulators of immune responses in cancer and have been directly implicated in promotion of tumor progression. However, the heterogeneity of these cells and lack of distinct markers hampers the progress in understanding of the biology and clinical importance of these cells. Using partial enrichment of PMN-MDSC with gradient centrifugation we determined that low density PMN-MDSC and high density neutrophils from the same cancer patients had a distinct gene profile. Most prominent changes were observed in the expression of genes associated with endoplasmic reticulum (ER) stress. Surprisingly, low-density lipoprotein (LDL) was one of the most increased regulators and its receptor oxidized LDL receptor 1

Identifiers

PMID28417112
PMCPMC5391495
OpenAlexW2488076079

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.