ArticleThe Korean journal of pain2017
Antinociceptive effect of intrathecal sec-O-glucosylhamaudol on the formalin-induced pain in rats.
Article in The Korean journal of pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
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- Anti-Pyretic, Analgesic, and Anti-Inflammatory Activities of Meloxicam and Curcumin Co-Encapsulated PLGA Nanoparticles in Acute Experimental Models.Metabolites · 2023Article
- Therapeutic Potential ofAntioxidants (Basel, Switzerland) · 2023Article
- Transcriptomics explores the potential of flavonoid in non-medicinal parts ofFrontiers in plant science · 2023Article
- Comparative Analysis of Coumarin Profiles in Different Parts ofMolecules (Basel, Switzerland) · 2022Article
- Article
- Sec-O-glucosylhamaudol mitigates inflammatory processes and autophagy via p38/JNK MAPK signaling in a rat neuropathic pain model.The Korean journal of pain · 2021Article
- Acetylcholinesterase and butyrylcholinesterase inhibitory activities of khellactone coumarin derivatives isolated from Peucedanum japonicum Thurnberg.Scientific reports · 2020Article
- Antinociceptive effects of intrathecal cimifugin treatment: a preliminary rat study based on formalin test.Anesthesia and pain medicine · 2020Article
- Sec-O-glucosylhamaudol suppressed inflammatory reaction induced by LPS in RAW264.7 cells through inhibition of NF-κB and MAPKs signaling.Bioscience reports · 2020Article
- Effect of sec-O-glucosylhamaudol on mechanical allodynia in a rat model of postoperative pain.The Korean journal of pain · 2019Article
- Protective Effects ofNutrients · 2018Article
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5 authors.
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Abstract
backgroundThe root of
methodsMale Sprague-Dawley rats were implanted with an intrathecal catheter. Rats were randomly treated with a vehicle and SOG (10 µg, 30 µg, 60 µg, and 100 µg) before formalin injection. Five percent formalin was injected into the hind-paw, and a biphasic reaction followed, consisting of flinching and licking behaviors (phase 1, 0-10 min; phase 2, 10-60 min). Naloxone was injected 10 min before administration of SOG 100 µg to evaluate the involvement of SOG with an opioid receptor. Dose-responsiveness and ED50 values were calculated.
resultsIntrathecal SOG showed a significant reduction of the flinching responses at both phases in a dose-dependent manner. Significant effects were showed from the dose of 30 µg and maximum effects were achieved at a dose of 100 µg in both phases. The ED50 value (95% confidence intervals) of intrathecal SOG was 30.3 (25.8-35.5) µg during phase 1, and 48.0 (41.4-55.7) during phase 2. The antinociceptive effects of SOG (100 µg) were significantly reverted at both phases of the formalin test by naloxone.
conclusionsThese results demonstrate that intrathecal SOG has a very strong antinociceptive effect in the formalin test and it seems the effect is related to an opioid receptor.
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