Evidence map›Paper›PMID 28416952›Full record

ReviewTuberculosis and respiratory diseases2017

Asthma and the Risk of Rheumatoid Arthritis: An Insight into the Heterogeneity and Phenotypes of Asthma.

Mary Claire Rolfes, Young Jun Juhn, Chung-Il Wi, Youn Ho Sheen

Open access · diamondAbstract readReview
In one paragraph

Review in Tuberculosis and respiratory diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  11. Comorbidities in childhood-onset and adult-onset asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Article
  12. Article
  13. Review
  14. Article
  15. Article
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  17. Effect of montelukast on the expression of CD4Experimental and therapeutic medicine · 2018
    Article
  18. Article
  19. Multimorbidity medications and poor asthma prognosis.The European respiratory journal · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Mary Claire RolfesMayo Medical School, Rochester, MN, USA.
Young Jun JuhnDepartment of Pediatric and Adolescent Medicine/Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Chung-Il WiDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Youn Ho SheenDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic in Florida · USCHA University · KRMayo Clinic in Arizona · US

Funding

Identification and characterization of children with asthma-associated comorbidities through computational and immune phenotypingR01HL126667 · NHLBI · MAYO CLINIC ROCHESTER · PI JUHN, YOUNG J, LIU, HONGFANG · 2015 to 2022
$4.3M
Enhanced Ascertainment of Asthma Status Via Natural Language ProcessingR21AI116839 · NIAID · MAYO CLINIC ROCHESTER · PI JUHN, YOUNG J, WU, STEPHEN TZE-INN · 2015 to 2016
$437k
NHLBI NIH HHS R01 HL126667NIAID NIH HHS R21 AI116839
6 · The paper itself

Abstract

Asthma is traditionally regarded as a chronic airway disease, and recent literature proves its heterogeneity, based on distinctive clusters or phenotypes of asthma. In defining such asthma clusters, the nature of comorbidity among patients with asthma is poorly understood, by assuming no causal relationship between asthma and other comorbid conditions, including both communicable and noncommunicable diseases. However, emerging evidence suggests that the status of asthma significantly affects the increased susceptibility of the patient to both communicable and noncommunicable diseases. Specifically, the impact of asthma on susceptibility to noncommunicable diseases such as chronic systemic inflammatory diseases (e.g., rheumatoid arthritis), may provide an important insight into asthma as a disease with systemic inflammatory features, a conceptual understanding between asthma and asthma-related comorbidity, and the potential implications on the therapeutic and preventive interventions for patients with asthma. This review discusses the currently under-recognized clinical and immunological phenotypes of asthma; specifically, a higher risk of developing a systemic inflammatory disease such as rheumatoid arthritis and their implications, on the conceptual understanding and management of asthma. Our discussion is divided into three parts: literature summary on the relationship between asthma and the risk of rheumatoid arthritis; potential mechanisms underlying the association; and implications on asthma management and research.

Indexed as

Arthritis, RheumatoidAsthmaComorbidityEpidemiologyGenetic HeterogeneityPhenotypeRisk

Identifiers

PMID28416952
PMCPMC5392483
OpenAlexW2605576483

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.