ArticleNature genetics2017
Cassava haplotype map highlights fixation of deleterious mutations during clonal propagation.
Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
125 citing papers in PubMed.
- Translating functional molecular knowledge into crop-breeding success.Nature reviews. Genetics · 2026Review
- Measuring the change in deleterious mutation burden of barley germplasm conserved over one regeneration cycle.G3 (Bethesda, Md.) · 2026Article
- Genomic constraint and hypervariability correlate with fitness effects in elite tetraploid potato breeding material.PLoS genetics · 2026Article
- Genomic divergence, adaptation, and the genetic basis of quality traits in ancient walnut landraces and wild relatives.Horticulture research · 2026Article
- Article
- Strategies to improve on selection based on estimated breeding values.Genetics, selection, evolution : GSE · 2026Article
- Genome Variation Map: a platform for the analysis and integration of genomic variation.Nucleic acids research · 2026Article
- Advances and prospects of genomic-assisted breeding in roots, tubers, and banana crops.Frontiers in plant science · 2026Review
- Inbreeding depression in diploid potato: genetic basis, deleterious load, and breeding mitigation.Frontiers in plant science · 2026Review
- Validation of single nucleotide polymorphism markers associated with hydrogen cyanide, total carotenoid and dry matter contents in cassava (Frontiers in plant science · 2026Article
- Exploring genetic diversity and selective signatures, a journey through Colombian cassava's landscape.Journal of plant research · 2026Article
- Allelic differences within DNA polymerase delta subunit 1 correlate with geminivirus resistance in diverse plants.G3 (Bethesda, Md.) · 2025Article
- Developing pangenomes for large and complex plant genomes and their representation formats.Journal of advanced research · 2025Review
- The Evolutionary Dynamics of Genetic Mutational Load Throughout Tomato Domestication History.Molecular ecology · 2025Article
- Cytological and Ploidy Analyses Revealing Fertility Defects of CultivarPlants (Basel, Switzerland) · 2025Article
- Review
- Accumulating Heterozygous Deleterious Mutations in Conserved Soybean Germplasm over Successive Regenerations.Plants (Basel, Switzerland) · 2025Article
- In silico prediction of variant effects: promises and limitations for precision plant breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Unraveling genetic diversity and population structure of pineapple germplasm using genome-wide SNP markers.Molecular genetics and genomics : MGG · 2025Article
- A BAC-guided haplotype assembly pipeline increases the resolution of the virus resistance locus CMD2 in cassava.Genome biology · 2025Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cassava (Manihot esculenta Crantz) is an important staple food crop in Africa and South America; however, ubiquitous deleterious mutations may severely decrease its fitness. To evaluate these deleterious mutations, we constructed a cassava haplotype map through deep sequencing 241 diverse accessions and identified >28 million segregating variants. We found that (i) although domestication has modified starch and ketone metabolism pathways to allow for human consumption, the concomitant bottleneck and clonal propagation have resulted in a large proportion of fixed deleterious amino acid changes, increased the number of deleterious alleles by 26%, and shifted the mutational burden toward common variants; (ii) deleterious mutations have been ineffectively purged, owing to limited recombination in the cassava genome; (iii) recent breeding efforts have maintained yield by masking the most damaging recessive mutations in the heterozygous state but have been unable to purge the mutation burden; such purging should be a key target in future cassava breeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.