ArticleMolecular psychiatry2018
The joint impact of cognitive performance in adolescence and familial cognitive aptitude on risk for major psychiatric disorders: a delineation of four potential pathways to illness.
Article in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Prefrontal networks dynamically related to recovery from major depressive disorder: a longitudinal pharmacological fMRI study.Translational psychiatry · 2019Trial
- Attention deficit hyperactivity disorder: transition to psychotic disorders.Molecular psychiatry · 2026Review
- Rethinking schizophrenia: insights from genomics and implications for research.Molecular psychiatry · 2026Review
- Parental income and drug use disorder among second-generation individuals in Sweden: effect modification by immigrant background and region of origin.BMC public health · 2026Article
- Effects of Shared and Nonshared Schizophrenia and Bipolar Disorder Alleles on Cognition and Educational Attainment in the UK Biobank.Biological psychiatry global open science · 2025Article
- Changes in the association between educational achievement, attainment and subsequent mental health: A survival analysis of 21 Swedish graduation cohorts.BMC public health · 2024Article
- [Advances in Mendelian randomization studies on autism spectrum disorder].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Risk for psychiatric and substance use disorders as a function of transitions in Sweden's public educational system: a national study.Psychological medicine · 2024Article
- Multivariate prediction of cognitive performance from the sleep electroencephalogram.NeuroImage · 2023Article
- School achievement in adolescence and the risk of mental disorders in early adulthood: a Finnish nationwide register study.Molecular psychiatry · 2023Article
- Associations between parental socioeconomic-, family-, and sibling status and risk of eating disorders in offspring in a Danish national female cohort.The International journal of eating disorders · 2022Article
- Is genetic liability to ADHD and ASD causally linked to educational attainment?International journal of epidemiology · 2022Article
- An Integrated Account of Expert Perspectives on Functioning in Schizophrenia.Journal of clinical medicine · 2021Article
- Young men's behavioral competencies and risk of alcohol use disorder in emerging adulthood: Early protective effects of parental education.Development and psychopathology · 2021Article
- Distinct Polygenic Score Profiles in Schizophrenia Subgroups With Different Trajectories of Cognitive Development.The American journal of psychiatry · 2020Article
- Academic performance, externalizing disorders and depression: 26,000 adolescents followed into adulthood.Social psychiatry and psychiatric epidemiology · 2019Article
- Functioning in schizophrenia from the perspective of psychologists: A worldwide study.PloS one · 2019Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
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Abstract
How do joint measures of premorbid cognitive ability and familial cognitive aptitude (FCA) reflect risk for a diversity of psychiatric and substance use disorders? To address this question, we examined, using Cox models, the predictive effects of school achievement (SA) measured at age 16 and FCA-assessed from SA in siblings and cousins, and educational attainment in parents-on risk for 12 major psychiatric syndromes in 1 140 608 Swedes born 1972-1990. Four developmental patterns emerged. In the first, risk was predicted jointly by low levels of SA and high levels of FCA-that is a level of SA lower than would be predicted from the FCA. This pattern was strongest in autism spectrum disorders and schizophrenia, and weakest in bipolar illness. In these disorders, a pathologic process seems to have caused cognitive functioning to fall substantially short of familial potential. In the second pattern, seen in the internalizing conditions of major depression and anxiety disorders, risk was associated with low SA but was unrelated to FCA. Externalizing disorders-drug abuse and alcohol use disorders-demonstrated the third pattern, in which risk was predicted jointly by low SA and low FCA. The fourth pattern, seen in eating disorders, was directly opposite of that observed in externalizing disorders with risk associated with high SA and high FCA. When measured together, adolescent cognitive ability and FCA identified four developmental patterns leading to diverse psychiatric disorders. The value of cognitive assessments in psychiatric research can be substantially increased by also evaluating familial cognitive potential.
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