ArticleProceedings of the National Academy of Sciences of the United States of America2017
Inducing protein aggregation by extensional flow.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- SIGMA: Shear-induced gelation by microbead aggregation in tubular flow systems.Materials today. Bio · 2026Article
- Amyloid-induced mineralization: From biological systems to biomimetic materials.Bioactive materials · 2025Review
- The interactions of non-functionalized polystyrene nanoparticles with human albumin and erythrocyte proteins: implications and potential consequences.Scientific reports · 2025Article
- The Mechanical Properties of Erythrocytes Are Influenced by the Conformational State of Albumin.Cells · 2025Review
- In the flow, how fluid dynamics shapes amyloid formation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Initiation of transthyretin aggregation at neutral pH by fluid agitation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- AggNet: Advancing protein aggregation analysis through deep learning and protein language model.Protein science : a publication of the Protein Society · 2025Article
- Rationalizing mAb Candidate Screening Using a Single Holistic Developability Parameter.Molecular pharmaceutics · 2025Article
- Article
- Aggregation of Transthyretin by Fluid Agitation.bioRxiv : the preprint server for biology · 2024Article
- Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation.Circulation research · 2024Article
- Amyloid and collagen templates in aortic valve calcification.Trends in molecular medicine · 2024Article
- Chaperone BiP controls ER stress sensor Ire1 through interactions with its oligomers.Life science alliance · 2024Article
- Single molecule delivery into living cells.Nature communications · 2024Article
- Silver nanoparticles alter the dimerization of AβRSC advances · 2024Article
- Article
- Biophysical Analysis of Therapeutic Antibodies in the Early Development Pipeline.Biologics : targets & therapy · 2024Review
- The role of flow in the self-assembly of dragline spider silk proteins.Biophysical journal · 2023Article
- Rotational Dynamics of a Protein under Shear Flow Studied by the Eckart Frame Formalism.The journal of physical chemistry. B · 2023Article
- Mimicking Kidney Flow Shear Efficiently Induces Aggregation of LECT2, a Protein Involved in Renal Amyloidosis.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Relative to other extrinsic factors, the effects of hydrodynamic flow fields on protein stability and conformation remain poorly understood. Flow-induced protein remodeling and/or aggregation is observed both in Nature and during the large-scale industrial manufacture of proteins. Despite its ubiquity, the relationships between the type and magnitude of hydrodynamic flow, a protein's structure and stability, and the resultant aggregation propensity are unclear. Here, we assess the effects of a defined and quantified flow field dominated by extensional flow on the aggregation of BSA, β
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