ArticleThe Journal of experimental medicine2017
Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs.
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Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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66 citing papers in PubMed, 116 citations in OpenAlex.
- Systematic investigation reveals extensive Epstein-Barr virus transcriptional regulation of the human genome.Cell genomics · 2026Article
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- Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells.Immunity · 2026Article
- E3 ligase UHRF2 hijacks nuclear TBK1 to epigenetically repress type I interferons expression.International journal of biological sciences · 2026Article
- CXXC5 is a ubiquitinated protein and is degraded by the ubiquitin-proteasome pathway.Protein science : a publication of the Protein Society · 2025Article
- DNA dioxygenase TET2 deficiency aggravates sepsis-induced acute lung injury by targeting ITGA10 via the PI3K/AKT signaling pathway.Cellular & molecular biology letters · 2025Article
- Autophagy-mediated TET2 degradation by ALV-J Env protein suppresses innate immune activation to promote viral replication.Journal of virology · 2025Article
- Signal integrator function of CXXC5 in Cancer.Cell communication and signaling : CCS · 2025Review
- Coactivator networks orchestrating noncanonical AR programs in enzalutamide-resistant CRPC.Frontiers in oncology · 2025Review
- Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.Frontiers in genetics · 2025Article
- DNA 5mC and RNA mInternational journal of molecular sciences · 2024Article
- Endogenous IL-22 contributes to the pathogenesis of salivary gland dysfunction in the non-obese diabetic model of Sjögren's syndrome.Molecular immunology · 2024Article
- Cutaneous clonal mature plasmacytoid dendritic cell dermatosis in patients with myeloid neoplasms.Blood advances · 2024Article
- Effect of LncRNA LOC106505926 on myogenesis and Lipogenesis of porcine primary cells.BMC genomics · 2024Article
- Correlation of DNA methylation of DNMT3A and TET2 with oral squamous cell carcinoma.Discover oncology · 2024Article
- Genomic determinants of antibody response to a typhoid vaccine in Indian recipients.Journal of genetics · 2024Article
- Single-cell profiling aligns CD56Frontiers in immunology · 2024Article
- Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53.Cell reports · 2023Article
- Inflammasome activity is controlled by ZBTB16-dependent SUMOylation of ASC.Nature communications · 2023Article
- Clonal haematopoiesis and dysregulation of the immune system.Nature reviews. Immunology · 2023Review
6 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors at 5 institutions in 2 countries.
Shixin MaCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai; CAS Center for Excellence in Molecular Cell Sciences; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-7701-1512
Xiaoling WanCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Zihou DengCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai; CAS Center for Excellence in Molecular Cell Sciences; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Lei ShiCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai; CAS Center for Excellence in Molecular Cell Sciences; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-2913-1747
Congfang HaoCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai; CAS Center for Excellence in Molecular Cell Sciences; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-3970-4457
Zhenyuan ZhouShanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
Chun ZhouCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai; CAS Center for Excellence in Molecular Cell Sciences; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Yiyuan FangCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Jinghua LiuCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai; CAS Center for Excellence in Molecular Cell Sciences; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-5502-8102
Jing YangCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai; CAS Center for Excellence in Molecular Cell Sciences; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Xia ChenCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai; CAS Center for Excellence in Molecular Cell Sciences; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Tiantian LiCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai; CAS Center for Excellence in Molecular Cell Sciences; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Aiping ZangCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai; CAS Center for Excellence in Molecular Cell Sciences; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Shigang YinCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Bin LiCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai; CAS Center for Excellence in Molecular Cell Sciences; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Joel PlumasInstitute for Advanced Biosciences (IAB), Team Immunobiology and Immunotherapy in Chronic Diseases, Institut National de la Santé et de la Recherche Médicale U1209, Centre National de la Recherche Scientifique UMR5309, Université Grenoble Alpes, Etablissement Français du Sang-Rhone-Alpes, F-38700 Grenoble, France.
Laurence ChaperotInstitute for Advanced Biosciences (IAB), Team Immunobiology and Immunotherapy in Chronic Diseases, Institut National de la Santé et de la Recherche Médicale U1209, Centre National de la Recherche Scientifique UMR5309, Université Grenoble Alpes, Etablissement Français du Sang-Rhone-Alpes, F-38700 Grenoble, France.ORCID 0000-0002-1479-9410
Xiaoming ZhangCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Guoliang XuState Key Laboratory of Molecular Biology, CAS Excellence Center in Molecular Cell Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Lubin JiangCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Nan ShenShanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
Sidong XiongInstitute of Biology and Medical Sciences, Soochow University, Soochow, Jiangsu 215006, China.
Xiaoming GaoInstitute of Biology and Medical Sciences, Soochow University, Soochow, Jiangsu 215006, China.
Yan ZhangCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Hui XiaoCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai; CAS Center for Excellence in Molecular Cell Sciences; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China huixiao@ips.ac.cn.ORCID 0000-0001-5304-243X
Institut Pasteur of Shanghai · CNChinese Academy of Sciences · CNSoochow University · CNCentre National de la Recherche Scientifique · FRShanghai Jiao Tong University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
TLR7/9 signals are capable of mounting massive interferon (IFN) response in plasmacytoid dendritic cells (pDCs) immediately after viral infection, yet the involvement of epigenetic regulation in this process has not been documented. Here, we report that zinc finger CXXC family epigenetic regulator CXXC5 is highly expressed in pDCs, where it plays a crucial role in TLR7/9- and virus-induced IFN response. Notably, genetic ablation of CXXC5 resulted in aberrant methylation of the CpG-containing island (CGI) within the
Indexed as
AnimalsCpG IslandsDendritic CellsDioxygenasesDNA-Binding ProteinsDNA MethylationEpigenesis, GeneticHerpes SimplexInterferonsIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsMiceMice, Inbred C57BLProto-Oncogene ProteinsToll-Like Receptor 7Toll-Like Receptor 9CXXC5 protein, mouseDioxygenasesDNA-Binding ProteinsInterferonsIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsProto-Oncogene ProteinsTet2 protein, mouseTlr7 protein, mouseTlr9 protein, mouseToll-Like Receptor 7Toll-Like Receptor 9Transcription Factors
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