Evidence map›Paper›PMID 28416609›Full record

ArticleThe Journal of biological chemistry2017

CD36 receptor regulates malaria-induced immune responses primarily at early blood stage infection contributing to parasitemia control and resistance to mortality.

Ramesh P Thylur, Xianzhu Wu, Nagaraj M Gowda, Kishore Punnath, Shivayogeeshwara E Neelgund, Maria Febbraio, D Channe Gowda

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Early enhanced control ofInfection and immunity · 2026
    Article
  2. Early enhanced control ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Human genetic variations conferring resistance to malaria.Journal of translational medicine · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Microglial activation states and their implications for Alzheimer's Disease.The journal of prevention of Alzheimer's disease · 2025
    Review
  8. Article
  9. High-Throughput CD36 Phenotyping on Human Platelets Based on Sandwich ELISA and Mutant Gene Analysis.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024
    Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Host genetics in malaria: lessons from mouse studies.Mammalian genome : official journal of the International Mammalian Genome Society · 2018
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ramesh P ThylurFrom the Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 and.
Xianzhu WuFrom the Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 and.
Nagaraj M GowdaFrom the Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 and.
Kishore PunnathFrom the Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 and.
Shivayogeeshwara E NeelgundFrom the Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 and.
Maria Febbraiothe Department of Dentistry, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
D Channe GowdaFrom the Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 and gowda@psu.edu.ORCID 0000-0002-6860-5108
Pennsylvania State University · USUniversity of Alberta · CA

Funding

Innate Immune Responses to Malaria ParasitesR01AI041139 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GOWDA, CHANNE D · 1998 to 2017
$5.8M
Malaria Research Training in South IndiaD43TW008268 · FIC · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GOWDA, CHANNE D · 2010 to 2015
$682k
FIC NIH HHS D43 TW008268NIAID NIH HHS R01 AI041139
6 · The paper itself

Abstract

In malaria, CD36 plays several roles, including mediating parasite sequestration to host organs, phagocytic clearance of parasites, and regulation of immunity. Although the functions of CD36 in parasite sequestration and phagocytosis have been clearly defined, less is known about its role in malaria immunity. Here, to understand the function of CD36 in malaria immunity, we studied parasite growth, innate and adaptive immune responses, and host survival in WT and

Indexed as

Immunity, HumoralAnimalsCD36 AntigensDendritic CellsHistocompatibility Antigens Class IIInterferon-gammaKiller Cells, NaturalMacrophagesMalariaMiceMice, KnockoutNeutrophilsParasitemiaPhagocytosisPlasmodium yoeliiTh1 CellsCD36 AntigensHistocompatibility Antigens Class IIIFNG protein, mouseInterferon-gammaCD36cellular immune responsecytokine inductionhumoral responseimmune regulationmalariaphagocytic receptorsphagocytosisPlasmodium yoeliiresistance to disease

Identifiers

PMID28416609
PMCPMC5454118
OpenAlexW2607175114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.