Evidence map›Paper›PMID 28416557›Full record

ArticleAntimicrobial agents and chemotherapy2017

Terbinafine Resistance of Trichophyton Clinical Isolates Caused by Specific Point Mutations in the Squalene Epoxidase Gene.

Tsuyoshi Yamada, Mari Maeda, Mohamed Mahdi Alshahni, Reiko Tanaka, Takashi Yaguchi, Olympia Bontems, Karine Salamin, Marina Fratti, Michel Monod

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 1 pooled it
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 1 synthesis or guideline pooled it, 326 citations in OpenAlex.

  1. Pooled it
  2. Correlation ofAntimicrobial agents and chemotherapy · 2018
    Trial
  3. Review
  4. Deciphering the genomic landscape ofMicrobial genomics · 2026
    Article
  5. Article
  6. Emerging Global Patterns of Terbinafine Resistance inAntibiotics (Basel, Switzerland) · 2026
    Review
  7. Dermatophytosis: An Update on Global Epidemiology.Journal of fungi (Basel, Switzerland) · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Global Emergence ofInfection and drug resistance · 2026
    Review
  14. Rising antifungal resistance inFrontiers in microbiology · 2026
    Review
  15. Article
  16. Emerging antifungal resistance inEmerging microbes & infections · 2025
    Article
  17. Recalcitrant dermatophytosis due toMedical mycology case reports · 2025
    Article
  18. National Belgian Study on Terbinafine Resistance inJournal of fungi (Basel, Switzerland) · 2025
    Article
  19. Article
  20. Article

78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Tsuyoshi YamadaTeikyo University Institute of Medical Mycology, Tokyo, Japan.
Mari MaedaTeikyo University Institute of Medical Mycology, Tokyo, Japan.
Mohamed Mahdi AlshahniGeneral Medical Education and Research Center, Teikyo University, Tokyo, Japan.
Reiko TanakaMedical Mycology Research Center, Chiba University, Chiba, Japan.
Takashi YaguchiMedical Mycology Research Center, Chiba University, Chiba, Japan.
Olympia BontemsService de Dermatologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Karine SalaminService de Dermatologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Marina FrattiService de Dermatologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Michel MonodService de Dermatologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland Michel.Monod@chuv.ch.
University Hospital of Lausanne · CHTeikyo University · JPChiba University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Terbinafine is one of the allylamine antifungal agents whose target is squalene epoxidase (SQLE). This agent has been extensively used in the therapy of dermatophyte infections. The incidence of patients with tinea pedis or unguium tolerant to terbinafine treatment prompted us to screen the terbinafine resistance of all

Indexed as

Antifungal AgentsArthrodermataceaeDrug Resistance, FungalMicrobial Sensitivity TestsNaphthalenesPoint MutationSqualene MonooxygenaseTerbinafineTrichophytonAntifungal AgentsNaphthalenesSqualene MonooxygenaseTerbinafineantifungal resistancedermatophytesreverse genetics approachsqualene epoxidaseterbinafineTrichophyton

Identifiers

PMID28416557
PMCPMC5487658
OpenAlexW2606000026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.