Evidence map›Paper›PMID 28416550›Full record

ArticleAntimicrobial agents and chemotherapy2017

Identification and Optimization of Thienopyridine Carboxamides as Inhibitors of HIV Regulatory Complexes.

Robert L Nakamura, Mark A Burlingame, Shumin Yang, David C Crosby, Dale J Talbot, Kitty Chui, Alan D Frankel, Adam R Renslo

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Robert L NakamuraAdvanced Genetic Systems, San Francisco, California, USA.
Mark A BurlingameSmall Molecule Discovery Center and Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA.
Shumin YangSchool of Medicine, Tsinghua University, Beijing, China.
David C CrosbyDepartment of Biochemistry and Biophysics, University of California, San Francisco, California, USA.
Dale J TalbotAdvanced Genetic Systems, San Francisco, California, USA.
Kitty ChuiAdvanced Genetic Systems, San Francisco, California, USA.
Alan D FrankelDepartment of Biochemistry and Biophysics, University of California, San Francisco, California, USA.
Adam R RensloSmall Molecule Discovery Center and Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA adam.renslo@ucsf.edu.ORCID 0000-0002-1240-2846

Funding

X-ray Screening and Rapid Structure DeterminationP50GM082250 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRANKEL, ALAN D · 2007 to 2018
$48.8M
Identification of Anti-HIV Lead Compounds Targeting RevR41AI076087 · NIAID · ADVANCED GENETIC SYSTEMS, INC. · PI RENSLO, ADAM R · 2009 to 2010
$848k
Genetic Assay for Inhibitors of RNA-Protein InteractionsR42CA103407 · NCI · ADVANCED GENETIC SYSTEMS, INC. · PI FRANKEL, ALAN D · 2005 to 2006
$820k
A small molecule screen to target viral RNA-protein complexesR43AI076143 · NIAID · ADVANCED GENETIC SYSTEMS, INC. · PI NAKAMURA, ROBERT · 2008 to 2008
$239k
Genetic Assay for Inhibitors of RNA-Protein InteractionsR41CA103407 · NCI · ADVANCED GENETIC SYSTEMS, INC. · PI FRANKEL, ALAN D · 2003 to 2003
$100k
NCI NIH HHS R41 CA103407NCI NIH HHS R42 CA103407NIAID NIH HHS R41 AI076087NIAID NIH HHS R43 AI076143NIGMS NIH HHS P50 GM082250
6 · The paper itself

Abstract

Viral regulatory complexes perform critical functions during virus replication and are important targets for therapeutic intervention. In HIV, the Tat and Rev proteins form complexes with multiple viral and cellular factors to direct transcription and export of the viral RNA. These complexes are composed of many proteins and are dynamic, making them difficult to fully recapitulate

Indexed as

Anti-HIV AgentsAntiviral AgentsGene Expression Regulation, ViralPyridinesRNA, ViralStructure-Activity RelationshipVirus ReplicationAnti-HIV AgentsAntiviral AgentsPyridinesRNA, ViralthienopyridineantiviralsHIVRevRNA

Identifiers

PMID28416550
PMCPMC5487668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.