Evidence map›Paper›PMID 28416533›Full record

ArticleGenome research2017

Capturing in vivo RNA transcriptional dynamics from the malaria parasite

Heather J Painter, Manuela Carrasquilla, Manuel Llinás

Abstract read
In one paragraph

Article in Genome research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Molecular mechanisms involved inFrontiers in microbiology · 2026
    Review
  5. Genetic analysis of pyrimidine biosynthetic enzymes inbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Adapt or Die: Targeting Unique Transmission-Stage Biology for Malaria Elimination.Frontiers in cellular and infection microbiology · 2022
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Transcriptional heterogeneity and tightly regulated changes in gene expression duringProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Heather J PainterDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Manuela CarrasquillaDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Manuel LlinásDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania 16802, USA.

Funding

Spatial Patterning During DevelopmentP50GM071508 · NIGMS · PRINCETON UNIVERSITY · PI POWELL, SUSAN M · 2004 to 2013
$30.6M
Novel antimalarial strategies using metabolomic network discoveryDP2OD001315 · OD · PRINCETON UNIVERSITY · PI LLINAS, MANUEL · 2007 to 2007
$2.4M
NIGMS NIH HHS P50 GM071508NIH HHS DP2 OD001315
6 · The paper itself

Abstract

To capture the transcriptional dynamics within proliferating cells, methods to differentiate nascent transcription from preexisting mRNAs are desired. One approach is to label newly synthesized mRNA transcripts in vivo through the incorporation of modified pyrimidines. However, the human malaria parasite,

Indexed as

Transcription, GeneticTransgenesBiotinCells, CulturedCytosine DeaminaseErythrocytesGene ExpressionHumansLife Cycle StagesOrganisms, Genetically ModifiedPentosyltransferasesPlasmodium falciparumPyrimidinesRecombinant Fusion ProteinsRNA, MessengerRNA, ProtozoanBiotinCytosine DeaminasePentosyltransferasesPyrimidinesRecombinant Fusion ProteinsRNA, MessengerRNA, ProtozoanSaccharomyces cerevisiae ProteinsStreptavidinuracil phosphoribosyltransferase

Identifiers

PMID28416533
PMCPMC5453321

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.