Evidence map›Paper›PMID 28416497›Full record

ArticleBMJ open2017

Prognostication in critically ill patients with severe traumatic brain injury: the TBI-Prognosis multicentre feasibility study.

Alexis F Turgeon, François Lauzier, Ryan Zarychanski, Dean A Fergusson, Caroline Léger, Lauralyn A McIntyre, Francis Bernard, Andrea Rigamonti, Karen Burns, Donald E Griesdale and 14 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Derivation and validation of actionable quality indicators targeting reductions in complications for injury admissions.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022
    Article
  5. Article
  6. Prognostication in patients with severe traumatic brain injury.African journal of thoracic and critical care medicine · 2020
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 11 institutions in 1 country.

Alexis F TurgeonPopulation Health and Optimal Health Practices Research Unit (Trauma-Emergency-Critical Care Medicine), CHU de Québec-Université Laval Research Centre, Québec City, Québec, Canada.ORCID 0000-0001-5675-8791
François LauzierPopulation Health and Optimal Health Practices Research Unit (Trauma-Emergency-Critical Care Medicine), CHU de Québec-Université Laval Research Centre, Québec City, Québec, Canada.
Ryan ZarychanskiDepartment of Internal Medicine, Section of Critical Care and of Haematology and Medical Oncology, University of Manitoba, Winnipeg, Manitoba, Canada.
Dean A FergussonClinical Epidemiology Unit, Center for Transfusion and Critical Care Research, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
Caroline LégerPopulation Health and Optimal Health Practices Research Unit (Trauma-Emergency-Critical Care Medicine), CHU de Québec-Université Laval Research Centre, Québec City, Québec, Canada.
Lauralyn A McIntyreClinical Epidemiology Unit, Center for Transfusion and Critical Care Research, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
Francis BernardDepartment of Medicine, Université de Montréal, Montréal, Québec, Canada.
Andrea RigamontiInterdepartmental Division of Critical Care Medicine, St-Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Karen BurnsInterdepartmental Division of Critical Care Medicine, St-Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Donald E GriesdaleDepartment of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.
Robert GreenDepartment of Critical Care Medicine, Department of Emergency Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Damon C ScalesInterdepartmental Division of Critical Care Medicine, Sunnybrook Hospital, University of Toronto, Toronto, Ontario, Canada.
Maureen O MeadeDepartment of Medicine, Division of Critical Care Medicine, McMaster University, Hamilton, Ontario, Canada.
Martin SavardDepartment of Medicine, Division of Neurology, Université Laval, Québec, Québec, Canada.
Michèle ShemiltPopulation Health and Optimal Health Practices Research Unit (Trauma-Emergency-Critical Care Medicine), CHU de Québec-Université Laval Research Centre, Québec City, Québec, Canada.
Jérôme PaquetDepartment of Surgery, Division of Neurosurgery, Université Laval, Québec, Québec, Canada.
Jean-Luc GariépyDepartment Radiology and Nuclear Medicine, Université Laval, Québec, Québec, Canada.
André LavoiePopulation Health and Optimal Health Practices Research Unit (Trauma-Emergency-Critical Care Medicine), CHU de Québec-Université Laval Research Centre, Québec City, Québec, Canada.
Kesh ReddyDepartment of Surgery, Division of Neurosurgery, McMaster University, Hamilton, Ontario, Canada.
Draga JichiciDepartment of Medicine, Division of Critical Care Medicine, McMaster University, Hamilton, Ontario, Canada.
Giuseppe PagliarelloDepartment of Critical Care Medicine, Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
David ZygunDepartment of Critical Care Medicine, University of Alberta, Edmonton, Alberta, Canada.
Lynne MoorePopulation Health and Optimal Health Practices Research Unit (Trauma-Emergency-Critical Care Medicine), CHU de Québec-Université Laval Research Centre, Québec City, Québec, Canada.
TBI-Prognosis Study Team and the Canadian Critical Care Trials Group
The Quebec Population Health Research Network · CAMcMaster University · CAUniversité Laval · CAUniversity of Ottawa · CASt. Michael's Hospital · CADalhousie University · CAUniversité de Montréal · CAUniversity of Alberta · CAUniversity of British Columbia · CAUniversity of Manitoba · CAUniversity of Toronto · CA

Funding

CIHR
6 · The paper itself

Abstract

objectiveSevere traumatic brain injury is a significant cause of morbidity and mortality in young adults. Assessing long-term neurological outcome after such injury is difficult and often characterised by uncertainty. The objective of this feasibility study was to establish the feasibility of conducting a large, multicentre prospective study to develop a prognostic model of long-term neurological outcome in critically ill patients with severe traumatic brain injury.

designA prospective cohort study.

setting9 Canadian intensive care units enrolled patients suffering from acute severe traumatic brain injury. Clinical, biological, radiological and electrophysiological data were systematically collected during the first week in the intensive care unit. Mortality and functional outcome (Glasgow Outcome Scale extended) were assessed on hospital discharge, and then 3, 6 and 12 months following injury. OUTCOMES: The compliance to protocolised test procedures was the primary outcome. Secondary outcomes were enrolment rate and compliance to follow-up.

resultsWe successfully enrolled 50 patients over a 12-month period. Most patients were male (80%), with a median age of 45 years (IQR 29.0-60.0), a median Injury Severity Score of 38 (IQR 25-50) and a Glasgow Coma Scale of 6 (IQR 3-7). Mortality was 38% (19/50) and most deaths occurred following a decision to withdraw life-sustaining therapies (18/19). The main reasons for non-enrolment were the time window for inclusion being after regular working hours (35%, n=23) and oversight (24%, n=16). Compliance with protocolised test procedures ranged from 92% to 100% and enrolment rate was 43%. No patients were lost to follow-up at 6 months and 2 were at 12 months.

conclusionsIn this multicentre prospective feasibility study, we achieved feasibility objectives pertaining to compliance to test, enrolment and follow-up. We conclude that the TBI-Prognosis prospective multicentre study in severe traumatic brain injury patients in Canada is feasible.

Indexed as

Trauma Severity IndicesAcute DiseaseAdultBrain Injuries, TraumaticCanadaCritical IllnessFeasibility StudiesFemaleGuideline AdherenceHumansLost to Follow-UpMaleMiddle AgedPrognosisProspective StudiesTime FactorsOutcomePilot studyPrognosisTraumatic brain injury

Identifiers

PMID28416497
PMCPMC5775467
OpenAlexW2606127074

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.