ArticleBMJ open2017
Long-term cost reduction of routine medications following a residential programme combining physical activity and nutrition in the treatment of type 2 diabetes: a prospective cohort study.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00917917 (Role of Combined Intervention of Physical Activity and Nutrition in Metabolic Syndrome Treatment on Cardio-vascular Risk and Muscular- Skeletal Functions in Human Subject. Analysis of Patient's Compliance in Patient's Follow-up.), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Combined Intervention of Physical Activity and Nutrition in Metabolic Syndrome Treatment on Cardio-vascular Risk and Muscular- Skeletal Functions in Human Subject. Analysis of Patient's Compliance in Patient's Follow-up.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of exercise training on heart rate variability in type 2 diabetes mellitus patients: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Dietary Fibres and the Management of Obesity and Metabolic Syndrome: The RESOLVE Study.Nutrients · 2020Trial
- New horizons in advancing lifestyle medicine for older adults utilizing a transdisciplinary approach: gaps and opportunities.Age and ageing · 2025Review
- Case Report: Abruptio placentae and epileptic seizure after occurrence of perinatal hyperglycaemia in woman with gestational diabetes mellitus and hypertriglyceridemia-induced acute pancreatitis.Frontiers in endocrinology · 2023Article
- Physical activity and healthcare utilization in France: evidence from the European Health Interview Survey (EHIS) 2014.BMC public health · 2022Article
- Article
- Italian guidelines for the treatment of type 2 diabetes.Acta diabetologica · 2022Article
- Article
- Administration of Jerusalem artichoke reduces the postprandial plasma glucose and glucose-dependent insulinotropic polypeptide (GIP) concentrations in humans.Food & nutrition research · 2022Article
- Improvement on Biometrics in Individuals Undergoing a 10 and 21-Day Lifestyle Intervention in a Lifestyle Medicine Clinic in Mexico.Journal of lifestyle medicine · 2021Article
- Emerging approaches to polypharmacy among older adults.Nature aging · 2021Review
- Use of Insulin Degludec/Insulin Aspart in the Management of Diabetes Mellitus: Expert Panel Recommendations on Appropriate Practice Patterns.Frontiers in endocrinology · 2021Review
- Evaluation of the Clinical and Economic Effects of a Primary Care Anchored, Collaborative, Electronic Health Lifestyle Coaching Program in Denmark: Protocol for a Two-Year Randomized Controlled Trial.JMIR research protocols · 2020Article
- Effects of recreational football on women's fitness and health: adaptations and mechanisms.European journal of applied physiology · 2018Review
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo demonstrate that lifestyle modifications will reduce the cost of routine medications in individuals with type 2 diabetes (T2D), through a mechanism involving glycaemic control.
designA within-trial cost-medication analysis with a 1-year time horizon.
settingControlled environment within the spa resort of Chatel-Guyon, France.
participantsTwenty-nine participants (aged 50-70 years) with T2D.
interventionsA 1-year follow-up intervention, beginning with a 3-week residential programme combining high exercise volume (15-20 hours/week), restrictive diet (-500 kcal/day) and education. Participants continued their routine medication, independently managed by their general practitioner.
main outcome measuresNumber of medications, number of pills, cost of medications and health-related outcomes.
resultsTwenty-six participants completed the 1-year intervention. At 1 year, 14 patients out of 26 (54%) stopped/decreased their medications whereas only 5 (19%) increased or introduced new drugs (χ
conclusionsIndividuals with T2D reduced routine medication costs following a long-term lifestyle intervention that started with a 3-week residential programme. Combining high exercise volume, restrictive diet and education effectively supported the health of T2D. The main factor explaining reduced medication costs was better glycaemic control, independent of weight changes. Despite limitations precluding generalisability, cost-effective results of reduced medication should contribute to the evidence base required to promote lifestyle interventions for individuals with T2D. TRIAL REGISTRATION NUMBER: NCT00917917; Post-results.
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